个人介绍:

吴虹教授长期致力于肿瘤分子遗传学的研究，重点探讨抑癌基因在肿瘤发生、发展及耐药中的分子机制。她所领导的团队在抑癌基因信号传递、肿瘤干细胞及基因工程动物模型等研究方面做了大量的杰出工作，其研究成果对于发现肿瘤发生的分子机制以及肿瘤治疗的新途径有重大的理论及实际意义。截至2025年2月，吴虹教授发表SCI收录科学论文170余篇，引用四万余次。基于她在肿瘤分子遗传学领域的重大贡献及卓越成就，曾获得皮尤学者（Pew Scholar）、霍华德休斯助理研究员（HHMI Assistant Investigator）等多项奖励和荣誉，并于2010年当选为美国科学促进会会士（Fellow of American Association for the Advancement of Science），2016年当选为欧洲分子生物学组织（European Molecular Biology Organization, EMBO）外籍院士。2013年吴虹教授入选国家级人才计划并于同年全职回国任北京大学生命科学学院讲席教授、北京大学生命科学学院院长，同时任北京大学-清华大学生命科学联合中心研究员。

教育经历:

1984 - 1991 , 博士 , 哈佛医学院
1978 - 1983 , 学士 , 北京医学院

工作经历:

2013- 至 今，北京大学讲席教授，北大-清华生命科学联合中心资深研究员　　
2013 - 2023 , 院长 , 北京大学生命科学学院
2011 - 2013 , 主任 , 美国加州大学洛杉矶分校分子医学研究所　　
2009 - 至今 , David Geffen Chair in Medical Research , 美国加州大学洛杉矶分校
2008 - 2011 , 副主任 正式成员 , 美国加州大学洛杉矶分校分子医学研究所
1997 - 2004 , 助理研究员 , 霍华德-休斯医学研究所
1996 - 2013 , 助理教授、副教授、教授 , 美国加州大学洛杉矶分校分子与医学药理学系
1991 - 1996 , 博士后 , 麻省理工学院Whitehead研究所

荣誉奖励:

北京市科学技术奖，2021
欧洲分子生物所组织外籍院士，2016
美国科学促进会会士，2011
霍华德休斯助理研究员，1997
皮尤学者奖，1997

学术任职:

2023年至今，北京大学生命科学学院学术委员会主任
2022年至今，北京大学学术委员会委员
2022年至今，美国癌症研究协会（AACR）亚洲/亚裔美国人工作组成员
2021年至今，北京大学教育基金会理事
2021年至今，北京大学兰园书院学术委员会主任
2019年至今，深圳湾实验室学术委员会副主任
2017年至今，北大-华东生物技术研究所董事会主席
2017年至今，北京大学-勃林格殷格翰战略合作项目北京大学联系人
2015-2020年，教育部科学技术委员会委员
2014-2016年，海外人才生物医学研究分会主任
2014年至今，北京大学-拜耳战略合作项目北京大学联系人
2013-2023年，北大-清华生命科学联合中心学术委员会委员
2013-2020年，美国癌症研究协会（AACR）国际事务委员会委员
2013-2023年，北京大学生命科学学院学术委员会副主任
2013-2016年，Movember全球咨询委员会委员

评审任职:

2023年，亚洲青年科学家奖指导委员会主席，生命科学领域评选委员会委员
2022年，亚洲青年科学家奖生命科学领域评选委员会主席

执教课程:

癌症：从机理到治疗

      吴虹课题组研究重点是结合肿瘤分子遗传学，基因组学，生物信息学及肿瘤模型，揭示癌症发生、发展及耐药的机制，寻找更有效的癌症靶向治疗、免疫治疗方法。主要的研究方向包括：
1. PTEN调控干细胞和肿瘤干细胞的分子遗传机制；
2. 癌细胞与肿瘤微环境的互作网络绘制；
3. 天然免疫及细胞坏死在前列腺癌进展中的作用机制；
4. 肿瘤发生过程中的代谢重编程。

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2. Chen T, Xie S, Cheng J, Zhao Q, Wu H*, Jiang P*, Du W*. (2024) AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis. Nat Commun. Jan 23;15(1):686.
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