2010.9 - 2015.7, Ph.D. in Chemical Biology, Peking University
2006.9 – 2010.7, B.S. in Chemistry, Peking University

2020.9 - present, Investigator, Peking-Tsinghua Centers for Life Sciences
2020.9 - present, Investigator, School of Life Sciences, Peking University
2015.11 - 2020.8, Postdoctoral Fellow, Department of Chemistry, The University of Chicago

Bayer Investigator, 2022
Peking University Boya Young Fellow, 2022
Yi Fang Investigator, 2021
Beijing Nova program, 2021

Our lab focuses on study the molecular mechanisms and biological functions of RNA modification and non-coding RNA. We integrate multiple research approaches including epigenetics, molecular biology, high-throughput sequencing, etc., to uncover the novel regulatory pathways of RNA modification/ncRNA on chromatin state and gene transcription, and to further explore their biological relevance in early embryo development, stem cell differentiation, autoimmune diseases, cancers and senescence.

1. Zihong Kang#, Ruimeng Li#, Chang Liu, Xiaozhe Dong, Yuxuan Hu, Lei Xu, Xinyu Liu, Yunfan Xiang, Liming Gao, Wenzhe Si, Lei Wang, Qing Li, Liang Zhang, Huan Wang, Xuerui Yang*, Jun Liu*, m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells, Cell, 2024, 187(21), 6035-6054.

2. Yini Li#, Xiaoyang Dou#, Jun Liu#, Yu Xiao#, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W Ostrow, Chuan He*, Shuying Sun*, Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration, Nature Neuroscience, 2023, 26(8): 1328-1338.

3. Xiaoyang Dou#, Lulu Huang#, Yu Xiao#, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He*, Jun Liu*, METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity, Protein & Cell, 2023, pwad009.

4. Jun Liu#, Xiaoyang Dou#, Chuanyuan Chen#, Chuan Chen, Chang Liu, Meng Michelle Xu, Siqi Zhao, Bin Shen, Yawei Gao*, Dali Han*, Chuan He*, N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription, Science, 2020, 367(6477): 580-586.

5. Min Wang#; Jun Liu#; Yan Zhao#; Ruizhi He#; Xiaodong Xu#; Xingjun Guo; Xu Li; Simiao Xu; Ji Miao; Jianpin Guo; Hang Zhang; Jun Gong; Feng Zhu; Rui Tian; Chengjian Shi; Feng Peng; Yechen Feng; Shuo Yu; Yu Xie; Jianxin Jiang; Min Li*; Wenyi Wei*; Chuan He*; Renyi Qin*; Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer, Molecular Cancer, 2020, 19(130).

6. Dali Han#*, Jun Liu#, Chuanyuan Chen, Lihui Dong, Yi Liu, Renbao Chang, Xiaona Huang, Yuanyuan Liu, Jianying Wang, Urszula Dougherty, Marc B Bissonnette, Bin Shen, Ralph R Weichselbaum, Meng Michelle Xu*, Chuan He*, Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells, Nature, 2019, 566(7743): 270-274.

7. Jiajie Hou#*; He Zhang#; Jun Liu#; Zhenjun Zhao; Jianye Wang; Zhike Lu; Bian Hu; Jiankui Zhou; Zhicong Zhao; Mingxuan Feng; Haiyan Zhang; Bin Shen; Xingxu Huang; Beicheng Sun; Chuan He*; Qiang Xia*; YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma, Molecular Cancer, 2019, 18(163).

8. Jun Liu#, Mark A Eckert#, Bryan T Harada#, Song-Mei Liu#, Zhike Lu, Kangkang Yu, Samantha M Tienda, Agnieszka Chryplewicz, Allen C Zhu, Ying Yang, Jing-Tao Huang, Shao-Min Chen, Zhi-Gao Xu, Xiao-Hua Leng, Xue-Chen Yu, Jie Cao, Zezhou Zhang, Jianzhao Liu, Ernst Lengyel*, Chuan He*, m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer, Nature Cell Biology, 2018, 20(9): 1074-1083.

9. Jun Liu#; Guanzheng Luo#; Juan Sun; Lili Men; Honggang Ye; Chuan He; Decheng Ren*; METTL14 is essential for β-cell survival and insulin secretion, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019, 1865(9): 2138-2148.

10. Yanan Yue#; Jun Liu#; Xiaolong Cui#; Jie Cao#; Guanzheng Luo; Zezhou Zhang; Tao Cheng; Minsong Gao; Xiao Shu; Honghui Ma; Fengqin Wang; Xinxia Wang; Bin Shen; Yizhen Wang; Xinhua Feng; Chuan He*; Jianzhao Liu*; VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation, Cell Discovery, 2018, 4(10).

11. Jun Liu#; Bryan T Harada#; Chuan He; Regulation of gene expression by N6-methyladenosine in cancer, Trends in Cell Biology, 2019, 29(6): 487-499.

(#co-authors contributed equally; *Corresponding authors)

The Leading Edges of Biochemistry and Molecular Biology, undergraduate course

The Basic Principle of Modern Biology (I), graduate course

Laboratory Introduction