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邓宏魁
邮  箱: hongkui_deng(AT)pku.edu.cn
职  称:
教授
办公室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
实验室主页: http://
个人主页: http://
个人简历
个人介绍文字
邓宏魁,北京大学博雅讲席教授、长江特聘教授,北京大学干细胞研究中心主任。清华-北大生命科学联合中心成员。2010-2016年当选为国际干细胞生物学学会(ISSCR)理事会理事,目前担任 Cell及Cell Stem Cell等杂志的编委。在Nature、Science、Cell、Cell Stem Cell等期刊发表论文100余篇, 论文被引用1万余次。在干细胞研究领域做出多项开创性的贡献,尤其在小分子化合物诱导细胞命运转变方面在国际上做出了一系列开拓性工作:1)利用化学小分子建立了一种全新的具有全能性特征的干细胞(Extended Pluripotent Stem Cells, EPS细胞)(Cell 2017);2)首次实现完全使用小分子化合物逆转“发育时钟”,让小鼠体细胞重新获得多潜能性(Science 2013),该成果开创了全新的体细胞重编程体系;3)建立了一套更高效的利用小分子化合物诱导化学多潜能干细胞(CiPSC)的方案(Cell 2015),揭示了化学重编程不同于传统重编程的分子机制; 4)实现小分子化合物诱导小鼠体细胞成为功能性神经元(Cell Stem Cell 2015),通过结合信号通路和染色质结构调节实现对细胞命运的操纵成为细胞重编程研究的新范式; 5)发现促进分化的关键基因可以替代多潜能性关键基因,实现体细胞重编程,并由此提出细胞命运决定的“跷跷板模型”(Cell 2013),为研究细胞命运决定提供了全新的视角。
教育经历
1990 - 1995 , 理学博士 , UCLA
1984 - 1987 , 理学硕士 , 上海第二医科大学
1980 - 1984 , 理学学士 , 武汉大学
工作经历
1995-1997 美国纽约大学医学中心Skirball Institute,博士后研究
1998-2000 美国麻省ViaCell 公司,分子生物学主任
2001-   北京大学,教育部长江学者特聘教授
2011-   北大-清华生命科学中心,高级研究员                          
2013-   北京大学干细胞研究中心,主任                                            
2016-   北京大学博雅讲座教授
荣誉奖励
1995 Aaron Diamond Postdoctoral Fellowship
2000 Cheung Kong Scholarship
2001 自然科学基金杰出青年基金
2005 Bill and Melinda Gates Foundation Grand Challenge Grant
2006 Lilly-Asian Scientific Excellence Award
2010 Sanofi-Aventis / Cell Research Outstanding Paper Award
2013 Wuxi PharmaTech Life Science Outstanding Achievements Awards
2014 谭家帧生命科学成就奖
2015 Innovation Award,CSSCR-Leica
2017 WuJieping-Paul Janssen Medical & Pharmaceutical Award
学术任职
2010-2016  Board of Director, International Society for Stem Cell Research
  
杂志任职
2013- Editorial Board Member, Cell
2013- Editorial Board Member, Cell Stem Cell
2013- Editorial Board Member, Stem Cell Report,
2012- Editorial Board Member, Stem Cells Translational Medicine
2011- Editorial Board Member, Journal of Molecular Cell Biology
2010- Editorial Board Member, Cell Research

科研领域描述
本实验室主要兴趣在于:体细胞重编程;细胞命运调控;再生医学
我们的主要研究方向是如何通过调控细胞命运获得多潜能干细胞和各种功能性细胞。生命的本质是化学过程,化学小分子调控细胞命运理论上是最有效的方式。我们研究团队建立了化学小分子调控细胞命运的技术手段,首次利用化学小分子将小鼠体细胞诱导成为多潜能干细胞和功能性神经元,不仅有助于更好地理解细胞命运决定和转变机制,而且为未来再生医学治疗重大疾病带来新的可能。我们团队利用化学小分子首次在体外建立了具有全能性特征的干细胞(EPS细胞),该细胞具有更强的发育潜能,为体外制备各种功能成熟的细胞类型提供了更好的来源。我们将利用EPS细胞通过定向分化制备功能性的血液细胞、胰岛细胞、肝脏细胞,并结合基因编辑技术制备新型抗肿瘤的CAR-T细胞,为治疗重大疾病提供新的解决方案。

代表性论文
1. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, Xu Y, Dong J, Wang C, Lai W, Zhu J, Xiong L, Zhu D, Li X, Yang W, Yamauchi T, Sugawara A, Li Z, Sun F, Li X, Li C, He A, Du Y, Wang T, Zhao C, Li H, Chi X, Zhang H, Liu Y, Li C, Duo S, Yin M, Shen H, Belmonte JC, Deng H. Cell. 2017; 169(2):243-257.

2. Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Li X, Liu D, Ma Y, Du X, Jing J, Wang L, Xie B, Sun D, Sun S, Jin X, Zhang X, Zhao T, Guan J, Yi Z, Lai W, Zheng P, Huang Z, Chang Y, Chai Z, Xu J, Deng H. Cell Stem Cell. 2017;21(2):264-273.

3. CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo. Xu L, Yang H, Gao Y, Chen Z, Xie L, Liu Y, Liu Y, Wang X, Li H, Lai W, He Y, Yao A, Ma L, Shao Y, Zhang B, Wang C, Chen H, Deng H. Mol Ther. 2017;25(8):1782-1789.

4. Zhao Y, Zhao T, Guan J, Zhang X, Fu Y, Ye J, Zhu J, Meng G, Ge J, Yang S, Cheng L, Du Y, Zhao C, Wang T, Su L, Yang W, Deng H. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming. Cell, 2015, 163, 1678-91.

5. Li X, Zuo X, Jing J, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z, Zhao Y, Deng H. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015, 17:195-203.

6. Xu J, Du Y, Deng H. Direct lineage reprogramming: strategies, mechanisms, and applications. Cell Stem Cell. 2015, 16(2):119-34. Review

7. Fang R, Liu K, Zhao Y, Li H, Zhu D, Du Y, Xiang C, Li X, Liu H, Miao Z, Zhang X, Shi Y, Yang W, Xu J, Deng H. Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts. Cell Stem Cell. 2014; 15(4):488-96.

8. Du Y, Wang J, Jia J, Song N3 Xiang C, Xu J, Hou Z, Su X, Liu B, Jiang T, Zhao D, Sun Y, Shu J, Guo Q, Yin M, Sun D, Lu S, Shi Y, Deng H , Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming , Cell Stem Cell , 2014 , 14:3 94-403  

9. Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. , Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds , Science , 2013 , 341(6146): 651-4.

10. Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C, Zhao Y, Deng H , Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell, 2013, 153(5): 963-75  

11. Sun X, Xu J, Lu H, Liu W, Miao Z, Sui X, Liu H, Su L, Du W, He Q, Chen F, Shi Y, Deng H. , Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo , Cell Stem Cell , 2013, 13(2): 230-6  

12. Zhao D, Chen S, Duo S, Xiang C, Jia J, Guo M, Lai W, Lu S, Deng H , Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects , Cell Research , 2013 , 23(1): 157-61  

13. Wang C, Tang X, Sun X, Miao Z, Lv Y, Yang Y, Zhang H, Zhang P, Liu Y, Du L, Gao Y, Yin M, Ding M, Deng H , TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy , Cell Research , 2012 , 22(1): 194-207  

14. Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res. 2011, 21(1):196-204.  

15. Yu C, Liu Y, Miao Z, Yin M, Lu W, Lv Y, Ding M, Deng H. Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors, Blood. 2010, 116(23):4786-94.

16. Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H and Ding S , Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors , Cell Stem Cell , 2009 , 4(1):16-9.

17. Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res. 2009, 19(4):429-38.

18. Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H , Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts , Cell Stem Cell , 2008 , 3(6):587-90.

19. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H , Two supporting factors greatly improve the efficiency of human iPSC generation , Cell Stem Cell , 2008 , 3(5):475-9.  

20. Zhang P, Li J, Wang C, Tan Z, Liu T, Chen L, Yong J, Jiang W, Sun X, Ding M, Deng H, , Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2008, 111(4): 1933-41.  

21. Wang C, Faloon P, Tan Z, Lv Y. Zhang P, Deng H, Xiong J. Mouse Lycat Controls the Development of Hematopoietic and Endothelial Lineages during in vitro ES Cell Differentiation. Blood, 2007, 110(10): 3601-9.

22. Cai J, Zhao Y, Ye F, Liu Y, Song Zhi, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M, Deng H, , Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology, 2007, 45(5): 1229-1239.
  
23. Jiang W, Shi Y, Zhao D, Chen S, Yong J, Zhang J, Qing T, Sun X, Zhang P, Ding M and Deng H. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 2007, 17(4):333-44.

24. Shi Y, Hou L, Tang F, Jiang W, Wang P, Ding M, Deng H. Inducing Embryonic Stem Cells to Differentiate into Pancreatic Beta Cells by a Novel Three-Step Approach with Activin A and All-Trans Retinoic Acid. Stem Cells, 2005, 23(5): 656-62. 52.  

25. Deng H, Unutmaz D, Kewalramani V, Littman D. Expression cloning of novel coreceptors utilized by the simion and human immunodeficency viruses , Nature, 1997, 388:296-300.
  
26. Deng H, Liu R, Ellmeier W, Choe S, Untmaz D, Burkhart M, Marazio P, Marmon S, Sutton R., Hill C, Davis C, Peiper S, Schall T, Littman D, Landau N , Identification of a major co-receptor for primary isolates HIV-1 , Nature, 1996, 381:661-666.
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