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陈建国
邮  箱: chenjg(AT)pku.edu.cn
职  称:
教授
办公室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
个人简历
教育经历
1982 - 1985  研究生  浙江农业大学
1989 - 1994  研究生  北京大学生命科学学院
1997 - 1999  交换学生 东京大学医学部
工作经历
1999 - 至今 , 教授 , 北京大学生命科学学院
1999 - 2000 , 访问学者 , 香港科技大学生物学系
1997 - 1999 , 访问学者 , 东京大学医学部
1994 - 1999 , 副教授 , 北京大学生命科学学院
1985 - 1989 , 讲师 , 浙江农业大学生物技术中心
荣誉奖励
国家级教学成果奖二等奖 , 2005
北京市级高等教育教学成果奖一等奖 , 2004
全国高校精品课(细胞生物学) , 2003
北京市级高等教育教学成果奖二等奖 , 2001
北京市级高等教育教学成果奖二等奖 , 1997
国家杰出青年科学基金 , 1995
杂志编辑
北京大学学报 , 2005 - 至今
国际老年医学杂志,2015 - 至今
科研领域描述
本实验室主要兴趣在于:
  细胞骨架的结构与功能
  神经系统的发育及细胞分化
  细胞内膜系统

代表性论文
1. Yuqing Xia, Ning Huang, Zhiquan Chen, Fangyuan Li, Guiliang Fan, Dandan Ma, Jianguo Chen* & Junlin Teng*. CCDC102B functions in centrosome linker assembly and centrosome cohesion. Journal of Cell Sciences. Accepted.
2. Huang Ning, Donghui Zhang, Song Wang, Junlin Teng & Jianguo Chen. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating the localization of CP110-CEP97 complex at the mother centriole. Nature Communications. 2018. 9:4511. DOI: 10.1038/s41467-018-06990-9.
3. Zheng Pengli, qingzhou chen, Xiaoyu Tian, nannan qian, peiyuan chai, bing liu, Junjie Hu, Craig Blackstone, Desheng Zhu, Junlin Teng & Jianguo Chen. DNA Damage Triggers Tubular Endoplasmic Reticulum Extension to Promote Apoptosis by Facilitating ER-mitochondria Signaling. Cell Research. 2018. 28:833–854; https://doi.org/10.1038/ s41422-018-0065-z.
  RESEARCH HIGHLIGHT: Bock FJ, Tait SWG. p53 REEPs to sow ER-mitochondrial contacts. Cell Res. 2018 Sep;28(9):877-878. doi: 10.1038/s41422-018-0073-z.
4. Huang Ning, Yuqing Xia, Donghui Zhang, Song Wang, Yitian Bao, Runsheng He, Junlin Teng & Jianguo Chen. Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68. Nature Communications. 2017. 8:15057. DOI: 10.1038/ncomms15057.
5. Xu S, Y Xu, L Chen, Q Fang, S Song, J Chen and J Teng. RCN1 suppresses ER stress-induced apoptosis via calcium homeostasis and PERK–CHOP signaling. Oncogenesis. 2017. doi:10.1038/oncsis. 2017.6.
6. Li Yiding, Jiamin Xu, Yafeng Liu, Jia Zhu, Nan Liu, Wenbo Zeng, Ning Huang, Malte J Rasch, Haifei Jiang, Xiang Gu, Xiang Li, Minhua Luo, Chengyu Li, Junlin Teng, Jianguo Chen, Shaoqun Zeng, Longnian Lin, Xiaohui Zhang. A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning. Nature Neuroscience. 2017. doi:10.1038/nn.4517.
7. Zhou Haining, Tianning Wang, Tao Zheng, Junlin Teng, Jianguo Chen. Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Nature Communications,2016. 7, doi:10.1038/ncomms10151.
8. Chen Liang, Sizheng Xu, Yiwei Xu,Weiwei Lu, Lin Liu, Di Yue, Junlin Teng & Jianguo Chen , Cab45S Promotes Cell Proliferation throughSERCA2b Inhibition and Ca2+ Signaling , Oncogene , 2016 , 35: 35-46.
9. Lv Kaosheng, Liang Chen, Yuanjun Li, Pengli Zheng, Yingying Liu, Zenglong Li, Jianguo Chen, and Junlin Teng, Trip6 Promotes Dendritic Morphogenesis through Dephosphorylated GRIP1-dependent Myosin VI and F-actin Organization, J. Neurosci. 2015. 35(6):2559-2571.
10. Chen L, Xu S, Liu L, Wen X, Xu Y, Chen J* and Teng J*, Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP, Cell Death Dis. 2014. 5:e1219.
11. Qiao Wang, Birong Shen, Liang Chen, Pengli Zheng, Hui Feng, Qingsong Hao, Lin Liu, Xiao Liu, Sizheng Xu, Jianguo Chen*, and Junlin Teng*, Extracellular Calumenin Suppresses ERK1/2 Signaling and Cell Migration by Protecting Fibulin-1 from MMP-13-mediated Proteolysis, Oncogene, 2014, doi: 10.1038/onc.2014.52.
12. Wang Jingjing, Shan Chunyan, Cao Wenyuan, Zhang Chen, Teng Junlin, Chen Jianguo, SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface, Human Molecular Genetics, 2013, 22(24): 4888-4900.
13. Feng Hui, Liang chen, Qiao Wang, Birong Shen, Lin Liu, Pengli Zheng, Sizheng Xu, Xiao Liu, and Jianguo Chen, Junlin Teng, Calumenin-15 Facilitates Filopodia Formation by Promoting TGF-β Superfamily Cytokine GDF-15 TranscrIption, Cell Death and Disease, 2013, 4, e870; doi:10.1038/cddis.2013.403.
14. He Runsheng, Wu Qixi, Zhou Haining, Huang Ning, Chen Jianguo*, Teng Junlin*, Cep57 is required for cytokinesis by facilitating central spindle microtubule organization. J. Biol. Chem. 2013. 288(20): 14384-14390.
15. He Runsheng, Huang Ning, Bao Yitian, Zhou Haining, Teng Junlin, Chen Jianguo. LRRC45, A Novel Centrosome Linker Component, Is Required for Centrosome Cohesion. Cell Reports , 2013 , 4: 1100-1107.
16. Qiao Wang, Birong Shen, Pengli Zheng, Hui Feng, Yige Guo, Wenyuan Cao, Liang Chen, Xiao Liu, Guodong Zhao, Sizheng Xu, Weide Shen, Jianguo Chen, and Junlin Teng, BmCREC Is an ER-resident Protein and Required for ER/Golgi Morphology, J. Biol. Chem. 2013, 288(37):26649-26657.  
17. Miao Linqing, Teng Junling, Lin Jiqiang, Liao Xianzhi, and Chen Jianguo, 14-3-3 protein interact with neurofilament protein-L (NF-L) and regulate dynamic assembly of neurofilament, J Cell Sci, 2013, 126:427-436.
18. Wu Qixi, He Runsheng, Zhou Haining, Yu CH Albert, Zhang Bo, Teng Junlin and Chen Jianguo , Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity , Cell Res , 2012 , 22(9):1390-1401.
19. Liu Yingying, Lv Kaosheng, Li Zenglong, Yu CH Albert, Chen Jianguo and Teng Junlin. Pacsin1, a tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol. Chem. 2012. 287(47):39911-39924.
20. Wang Qiao, Teng Junlin, Shen Birong, Zhang Wei, Guo Yige, Su Xiaolei,Zhang Chuanxi, Yu Albert CH, Chen Jianguo. Characterization of Kinesin-like Proteins in Silkworm Posterior Silkgland Cells, Cell Res. 2010, 20: 713-727.
21. Huihui Li, Yan Guo, Junlin Teng, Mingxiao Ding. Albert Cheung Hoi Yu and Jianguo Chen. 14-3-3gamma affects dynamics and integrity of glial filaments by binding to phosphorylated GFAP, J. of Cell Science. 2006 , 119: 4452-4461.
22. Sang huaceng, Zhonghua Lu, Yulong Li, Binggen Ru, Wenqing Wang, and Jianguo Chen. Phosohorylation of GSK-3 beta in intact cells influences the stability of microtubules. Neuroscience Leter. 2003, 312:141-144.
23. Teng Junlin, Yosuke Takei, Akihiro Harada, Takao Nakata, Jianguo Chen and Nobutaka Hirokawa. Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J. Cell Biology. 2001, 155: 65-76.  
24. Chen, J., Nakata, T., Zhang, Z. and Hirokawa, N, The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. J. of Cell Science. 2000 , 113: 3861-3869.
25. Terunaga Nakagawa, Jianguo Chen, Zhizeng Zhang, Yoshimitsu Kanai, and Nobutaka Hirokawa, Two Distinct Function of the Carboxyl-terminal Tail Domain of NF-M upon Neurofilament Assembly: Cross-bridge Formation and Longitudinal Elongation of Filaments. J. Cell Biol. 1995. 129:411-429.
26. Kanai Y., Chen J. and Hirokawa N. Microtubule bundling by tau proteins in vivo: analysis of functional domains. EMBO J. 1992. 11, 3953 – 3961.
27. Chen, J., Kanai, Y., Cowan, N. J. and Hirokawa, N. Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons Nature. 1992. 360, 674 - 677.
执教课程
细胞生物学 , 主持人 , 北京大学 , 1994-2013 秋季学期
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