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张泽民
邮  箱: zeminz(AT)yahoo.com
职  称:
教授
办公室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
个人简历
代表性论文
1. C. Klijn, S. Durinck, E. Stawiski, P. M. Haverty, Z. Jiang, H. Liu, J. Degenhardt, O. Mayba, F. Gnad, ..., D. Stokoe, Z. Modrusan, R. M. Neve, F. J. de Sauvage, J. Settleman*, S. Seshagiri*, and Z. Zhang , A comprehensive transcriptional portrait of human cancer cell lines , Nature Biotechnology , 2015 , doi:10.1038/nbt.3080  
2. S. Jhunjhunwala, Z. Jiang, E. W. Stawiski, F. Gnad, J. Liu, O. Mayba, P. Du, J. Diao, C. Santos, K-F Wong, Z. Gao, Y. Li, S. Johnson, H. M. Stern, T. D. Wu, S. B. Kapadia, Z. Modrusan, J. M. Luk, D. M. French, S. Seshagiri, and Z. Zhang , Diverse modes of genomic alterations in hepatocellular carcinoma , Genome Biology , 2014 , 15:436  
3. O. Mayba, H. N. Gilbert, J. Liu, P. M. Haverty, S. Jhunjhunwala, Z. Jiang, C. Watanabe, and Z. Zhang , Allele specific expression detection in cancer tissues and cell lines by MBASED , Genome Biology , 2014 , 15:405  
4. J. Liu, M. McCleland, E. Stawiski, F. Gnad, P. M. Haverty, S. Durinck, ... , G. Manning, T. D. Wu, R. Neve, F. J. de Sauvage, Z. Modrusan, S. Seshagiri, R. Firestein, and Z. Zhang , Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer , Nature Communication , 2014 , 5:3830  
5. C. M. Rudin, S. Durinck, E. W. Stawiski, J. T. Poirier, Z. Modrusan, D. Shames, ..., Z. Zhang, H. Koeppen, T. D. Wu, H. M Stern, R. L. Yauch, K. E. Huffman, D. D. Paskulin, P. B. Illei, M. Varella-Garcia, A. F. Gazdar, F. J. de Sauvage, R. Bourgon, J. D. , Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small cell lung cancer , Nature Genetics , 2012 , 44: 1111-1116  
6. Z. Zhang , Genomic landscape of liver cancer , Nature Genetics , 2012 , 44: 1075-1077  
7. Z. Jiang*, S. Jhunihunwala*, J. Liu, P. Haverty, K. Pant, ..., C. Watanabe, J. Diao, S. Kapadia, F. de Sauvage, R. Gentleman, H. Stern, S. Seshagiri, Z. Modrusan, D. Ballinger, Z. Zhang , Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events , Genome Research , 2012 , 22:2315-2327  
8. J. Liu, W. Lee, Z. Chen, Z. Jiang, S. Jhunjhunwala, P. M Haverty, F. Gnad, ..., J. Minna, A. Gazdar, H. M. Stern, K. P. Hoeflich, T. D. Wu, F. J. de Sauvage, R. C. Gentleman, R. M. Neve, D. Stokoe, Z. Modrusan, S. Seshagiri, D. S. Shames, Z. Zhang , Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events , Genome Research , 2012 , 22:2315-2327  
9. S. Seshagiri, E. Stawiski, S. Durinck, Z. Modrusan, E. Storm, ..., H. Koeppan, R. Gentleman, T. K. Starr, Z. Zhang, D. A. Largaespada, T. D. Wu and F. J. de Sauvage , Recurrent R-spondin fusions in colon cancer , Nature , 2012 , 488, 660–664  
10. Z. Kan, B. S. Jaiswal, J. Stinson, V. Janakiraman, D. Bhatt, H. M. Stern, P. Yue, P. M. Haverty, R. Bourgon, J. Zheng, M. Moorhead, S. Chaudhuri, L. P. Tomsho, B. A. Peters, K. Pujara, S. Cordes, D. P. Davis, V. E. Carlton, W. Yuan, L. Li, W. Wang, C. , Diverse somatic mutation patterns and pathway alterations in human cancers , Nature , 2010 , 466: 869-873  
11. W. Lee, Z. Jiang, J. Liu, P. M. Haverty, Y. Guan, J. Stinson, P. Yue, Y. Zhang, K. P. Pant, ... , A. Pandita, D. G. Ballinger, R. Drmanac, Z. Modrusan, S. Seshagiri, and Z. Zhang , The mutation spectrum revealed by paired genome sequences from a lung cancer patient , Nature , 2010 , 465:473-477  
12. W. Lee, P. Yue, and Z. Zhang , Analytical methods for inferring functional effects of single base-pair substitutions in human cancers , Human Genetics , 2009 , 126:481-498  
13. L. S. Hon, Y. Zhang, J. S. Kaminker, and Z. Zhang , Computational prediction of the functional effects of amino acid substitutions in signal peptides using a model-based approach , Human Mutation , 2009 , 30 (1): 99-106  
14. J. Liu, Y. Zhang, X. Lei, and Z. Zhang , Natural selection of protein structural and functional properties: a SNP perspective , Genome Biology , 2008 , 9(4): R69  
15. L. D. Wood, D. W. Parsons, S. Jones, J. Lin, T. Sjöblom, R. J. Leary, D. Shen, S. M. Boca, T. Barber, J. Ptak, N. Silliman, S. Szabo, Z. Dezso, V. Ustyanksky, T. Nikolskaya, Y. Nikolsky, R. Karchin, P. A. Wilson, J. S. Kaminker, Z. Zhang, R. Croshaw, , The genomic landscapes of human breast and colorectal cancers , Science , 2007 , 318: 1108-1113  
16. N. Kayagaki, Q. Phung, S. Chan, R. Chaudhari, C. Quan, K. M. O'Rourke, M. Eby, E. Pietras, G. Cheng, J. F. Bazan, Z. Zhang, D. Arnott, and V. M. Dixit , DUBA: a deubiquitinase that regulates type I interferon production , Science , 2007 , 318: 1628-1632  
17. L. S. Hon and Z. Zhang , The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression , Genome Biology , 2007 , 8 (8): R166  
18. J. S. Kaminker, Y. Zhang, C. Watanabe, and Z. Zhang , CanPredict: A computational tool for predicting missense cancer-associated mutations , Nucleic Acids Research , 2007 , 35: W595-598  
19. Y. Zhang, S-M Luoh, L. S. Hon, R. Baertsch, W. I. Wood and Z. Zhang , GeneHub-GEPIS: Digital expression profiling for normal and cancer tissues based on an integrated gene database , Nucleic Acids Research , 2007 , 35: W152-158  
20. J. S. Kaminker, Y. Zhang, A. Waugh, P. Haverty, J. Stinson, B. Peters, D. Sebisanovic, W. F. Forrest, J. F. Bazan, S. Seshagiri, and Z. Zhang , Distinguishing cancer associated missense mutations from common polymorphisms , Cancer Research , 2007 , 67: 465-473  
21. Z. Zhang* and W. J. Henzel , Signal peptide prediction based on analysis of experimentally verified cleavage sites , Protein Science , 2004 , 13: 2819-2824  
22. Y. Zhang, D. Eberhard, G. D. Frantz, P. Dowd, T. D. Wu, C. Watanabe, Y. Zhou, P. Polakis, K. J. Hillan, W. I. Wood, and Z. Zhang , GEPIS – Quantitative gene expression profiling in normal and cancer tissues , Bioinformatics , 2004 , 20: 2390-2398  
23. E. Wertz, K. M. O’Rourke, Z. Zhang, D. Dornan, D. Arnott, R. J. Deshaies, and V. M. Dixit , Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase , Science , 2004 , 303: 1371-1374  
24. Y. Zhou, S-M. Luoh, Y. Zhang, C. Watanabe, T. D. Wu, M. Ostland, W. I. Wood, and Z. Zhang , Genome-wide identification of chromosome regions of increased tumor expression by transcriptome analysis , Cancer Research , 2003 , 63: 5781-5784  
25. J. LeCouter, J. Kowalski, J. Foster, P. Hass, Z. Zhang, L. Dillard-Telm, G. Frantz, L. Rangell, L. DeGuzman, G-A. Keller, F. Peale, A. Gurney, K. J. Hillan, and N. Ferrara , Identification of an angiogenic mitogen selective for endocrine gland endothelium , Nature , 2001 , 412: 877-884  
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