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张传茂
邮  箱: zhangcm(AT)pku.edu.cn
职  称:
教授
办公室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
个人简历
教育经历
1989-1993,博士,北京大学生命科学学院
1983-1986,硕士,南京农业大学畜牧兽医系
1977-1980,大专,河南省商邱农业学校兽医系
工作经历
2002 - 至今,教授,北京大学生命科学学院
1993-2002,副教授,北京大学生命科学学院
1999-2002, CRC Senior Traveling Research Fellow,英国丹迪大学.
1997-1999, BBSRC Senior Research Fellow,英国曼彻斯特大学
1995-1997,Wellcome Trust Senior Traveling Research Fellow,英国丹迪大学
社会服务工作
国家自然科学基金委第三届和第四届生命科学部专家咨询委员会委员;
国家自然科学基金委第十一届和第十二届生命科学部专家评审组成员;
国务院学位委员会评议组生物学组成员,2009 - 至今;
中国细胞生物学会常务理事,副秘书长;
中国生物物理学会常务理事;
中国生物物理学会第十届膜与细胞生物物理专业委员会副主任;
北京市细胞生物学会监事长;
教育部重点实验室主任;
北大生科院学位委员会副主席;
北大生科院学术委员会委员。
荣誉奖励
北京大学拜耳学者奖,2015
全国优秀科技工作者,2014;
北京市优秀博士学位论文指导教师奖;2011;
全国模范教师,2009;
北京市优秀教师,2009;
国家自然科学基金委员会“创新研究群体” I期(2005)和II期(2008)学术带头人;
国务院政府特殊津贴获得者,2008;
中国教育部及香港李嘉诚基金会‘长江学者’奖励计划,2005;
北京市级高等教育教学成果奖一等奖(丁明孝,陈建国,张传茂,苏都莫日根) ,2004;
《细胞生物学》全国高校精品课(丁明孝,陈建国,张传茂,苏都莫日根等),2003;
国家自然科学基金委员会“国家杰出青年科学基金”获得者,2003;
《细胞生物学》全国优秀教材奖一等奖(编者之一),2002;
中国国家自然科学奖二等奖(翟中和,张传茂,张博等七人),2001;
中国高校科学技术奖一等奖(翟中和,张传茂,张博等五人),2000;
杂志任职
编委,Cell Research (中国),2006 - ;
编委,The Journal of Biological Chemistry,2016 - ;
Associate editor,Biophysics Reports (中国),2014 - ;
编委,Chinese Science Bulletin (中国),2005 - ;
Review Editor,Frontiers in Cell and Developmental Biology(Switzerland),2014 -
科研领域描述
本实验室主要兴趣在于:
  细胞核结构与功能 细胞周期调控研究(包括纺锤体装配机理研究,DNA复制起始调控机理研究,核膜装配机理研究等) Ran GTPase 在细胞核物质运输和细胞周期调控中的作用 肿瘤细胞生物学(肿瘤细胞增殖调节和增殖控制)  
1,发现Ran GTPase 控制核膜装配(Science, 2000; Current Biology, 2011; Journal of Cell Science, 2012)。
2,发现Ran GTPase 控制纺锤体组装(Journal of Cell Science, 1999)。
3,建立了应用相关蛋白质小球和细胞(包括卵细胞)提取物为材料的非细胞体系核膜重建模式(Current Biology, 2001, 2002; European Journal of Cell Biology,2002)。
4, 发现核膜物质运输相关蛋白importin beta 参与核膜装配(Current Biology, 2002)。
5,发现Ran 调控核孔复合体装配(European Journal of Cell Biology, 2002)。
6,发现RCC1在染色体上定位所产生的Ran-GTP梯度是纺锤体正确装配所需要的(Current Biology, 2002)。
7,发现Ran GTPase 通过调控核膜物质运输进而调控DNA 复制(Journal of Cell Science,1998)。
8,以实验证明细胞核纤层(Nuclear lamina)对细胞核结构的维持和DNA 复制起重要调控作用(Journal of Cell Science,1996)。
9,发现Nucleoplasin在非洲爪蟾卵提取物细胞凋亡过程中调控染色质的凝集(PNAS, 2005)。
10,发现Aurora A/B, Plk1, Cdk1等激酶综合调控纺锤体装配(PNAS,2009;Cell Research, 2008, 2011; Journal of Cell Science, 2009, 2013a, 2013b)。  
代表性论文
1.Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang, Chuanmao Zhang*, DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. Journal of Cell Science, 2016,129:1429-1440 doi:10.1242/jcs.178723..
2.Boyan Zhang, Tingting Zhang, Guopeng Wang, Gang Wang, Wangfei Chi, Qing Jiang, Chuanmao Zhang* , GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis. PLoS Biology, 2015, 13(4): e1002129. doi:10.1371/journal.pbio.1002129.
3.Jingyan Fu,* Minglei Bian,* Guangwei Xin, Zhaoxuan Deng,Jia Luo,Xiao Guo, Hao Chen,Yao Wang, Qing Jiang, and Chuanmao Zhang* , TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. Journal of Cell Biology, 2015, 210 (3): 373–383.
4.Xiaolong Zhuo,* Xiao Guo,* Xiaoyan Zhang, Guihua Jing, Yao Wang, Qiang Chen, Qing Jiang, Junjun Liu,* and Chuanmao Zhang* , Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. Journal of Cell Biology, 2015, 210 (5): 727–735.
5.Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou*, Qing Jiang*, and Chuanmao Zhang*, Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B. Journal of Biological Chemistry, 2015, 290(28):17546–17558.
6.Ran Q,* Nan Xu,* Gang Wang, He Ren, Si Li, Jun Lei, Qiaoyu Lin, LihaoWang, Xin Gu, Hongyin Zhang, Qing Jiang,* and Chuanmao Zhang* , The lamin-A/C–LAP2–BAF1 protein complex regulates mitotic spindle assembly and positioning. Journal of Cell Science, 2015, 128: 2830-2841.
7.Wu, Yiran、Zhuo, Xiaolong、Dai, Ziwei、Guo, Xiao、Wang, Yao、Zhang, Chuanmao*、Lai, Luhua*,Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations. Mol Biosyst, 2015, 11(2): 497-505.
8.Zhang, Meiling; Sun, Tao; Jian, Chongshu; Lei, Lei; Han, Peidong; Lv, Quanlong; Yang, Ran; Zhou, Xiaohai; Xu, Jiejia; Hu, Yingchun; Men, Yongfan; Huang, Yanyi; Zhang, Chuanmao; Zhu, Xiaojun; Wang, Xianhua; Cheng, Heping; Xiong, Jing-Wei* , Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish. PLos One, 2015, 10(7), p e0132567.
9.Gang Wang, Qing Jiang and Chuanmao Zhang*, The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. Journal of Cell Science, 2014,127:4111-4122.
10.Han, Peidong;Zhou, Xiao-Hai;Chang, Nannan;Xiao, Cheng-Lu;Yan, Shouyu;Ren, He;Yang, Xin-Zhuang;Zhang, Mei-Ling;Wu, Qing;Tang, Boyang;Diao, Ju-Peng;Zhu, Xiaojun;Zhang, Chuanmao;Li, Chuan-Yun;Cheng, Heping;Xiong, Jing-Wei*,  Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Research, 2014, 24(9),1091-1107.
11.Zhige Wu, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang*, Phosphorylation of Crm1 by CDK1–cyclin-B promotes Ran-dependent mitotic spindle assembly, Journal of Cell Science, 2013, 126 (15):3417–3428.
12.Gang Wang, Qiang Chen, Xiaoyan Zhang, Boyan Zhang, Xiaolong Zhuo, Junjun Liu, Qing Jiang and Chuanmao Zhang*, PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry, Journal of Cell Science, 2013, 126 (6): 1355–1365.
13.Wenxiang Fu, Hao Chen, GangWang, Jia Luo, Zhaoxuan Deng, Guangwei Xin, Nan Xu, Xiao Guo, Jun Lei, Qing Jiang and Chuanmao Zhang*,  Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly, Proc. Natl. Acad. Sci. USA (PNAS), 2013, 110 (38) : 15295–15300.
14.Quanlong Lu, Zhigang Lu, Qinying Liu , Li Guo, He Ren, Jingyan Fu, Qing Jiang, Paul R Clarke, Chuanmao Zhang*, Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β. Cell Research, 2012, 22:1562-1575.
15.Yueguang Rong; Yuan Tian; Jianzhong Xi; Chuanmao Zhang; Hanshuo Zhang; Zhen Cao; She Chen; Wanqing Du; Lin Li; Ying Li; Mei Liu; Liang Ma; He Ren; Li Yu*, Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nature Cell Biology, 2012, 14(9):924-934.
16.Shiqi Wang; Weiming Xiao; Chuanmao Zhang; Yan Zhang; Juan Chen; Ming Chen; Quan Chen; Chunsun Jiang; Shouqin Lü; Sicong Shan; Mian Long*, Multi-patterned dynamics of mitochondrial fission and fusion in a living cell. PloS one, 2012, 7(5):e19879.
17.Hao-Di Wu, Ming Xu, Rong-Chang Li, Liang Guo, Ying-Si Lai, Shi-Ming Xu,Su-Fang Li, Quan-Long Lu , Lin-Lin Li, Hai-Bo Zhang, You-Yi Zhang, Chuan-Mao Zhang, and Shi-Qiang Wang*, Ultrastructural remodelling of Ca21 signalling apparatus in failing heart cells. Cardiovascular Research, 2012, 95, 430–438.
18.Wenxiang Fu, Qing Jiang and Chuanmao Zhang*,  Novel functions of endocytic player clathrin in mitosis. Cell Research, 2011, 21:1655-1661.
19.Xiu-Hua Xue, Chun-Qing Guo, Fei Du, Quan-Long Lu, Chuanmao Zhang and Hai-Yun Ren*, AtFH8 Is Involved in Root Development under Effect of Low-Dose Latrunculin B in Dividing Cells. Molecular Plant, 2011, 4(2):264–278.
20.Fu, J., Jiang, Q. & Zhang, C., Coordination of Cell Cycle Events by Ran GTPase. Nature Education ,2010, 3(9):32.
21.Fu, J., Jiang, Q. & Zhang, C., Collaboration of Mitotic Kinases in Cell Cycle Control. Nature Education, 2010, 3(9):82.
22.BIAN MingLei, FU JingYan, YAN Y, JIANG Qing, and ZHANG ChuanMao*,  Short Exposure to Paclitaxel Induces Multi-polar Spindle Formation and Aneuploidy through Promoting Acentrosomal Pole Assembly, CHINESE SCI BULL, 2010, 53(11):1322-1329.
23.Xuelong Lu, Yang Shi, Quanlong Lu, Yan Ma, Jia Luo, Qingsong Wang, Jianguo Ji, Qing Jiang and Chuanmao Zhang*, Requirement for lamin B receptor and its regulation by importin β and phosphorylation in nuclear envelope assembly during mitotic exit, J Biol Chem., 2010, 285: 33281–33293.
24.Wenxiang Fu, Wei Tao, Puwei Zheng, Jingyan Fu, Minglei Bian, Qing Jiang, Paul R Clarke and Chuanmao Zhang*, Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. Journal of Cell Science, 2010, 123, 3645-3651.
25.Qinying Liu, Jingying Yu, Xiaolong Zhuo, Qing Jiang and Chuanmao Zhang*, Pericentrin contains five NESs and an NLS essential for its nucleocytoplasmic trafficking during the cell cycle, Cell Research, 2010, 20:948–962.
26.Zhang J, Liu W, Liu J, Xiao W, Liu L, Jiang C, Sun X, Liu P, Zhu Y, Zhang C, Chen Q. G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nat Commun. 2010 Oct 19;1:101. doi: 10.1038/ncomms1099.
27.Qinying Liu, Qing Jiang and Chuanmao Zhang*, A fraction of Crm1 locates at centrosomes by its CRIME domain and regulates the centrosomal localization of pericentrin. Biochemical and Biophysical Research Communications, 2009, 384: 383-388.
28.Xiaoyan Zhang, Qiang Chen, Jia Feng, Junjie Hou, Fuquan Yang, Junjun Liu, Qing Jiang and Chuanmao Zhang*, Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the γTuRC to the centrosome, Journal of Cell Science, 2009,122, 2240-2251.
29.Jingyan Fu, Minglei Bian, Junjun Liu, Qing Jiang, and Chuanmao Zhang*, A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc. Natl. Acad. Sci. USA (PNAS), 2009, 106 (17):  6939–6944.
30.Fei Lu, Rongfeng Lan, Hongyin Zhang, Qing Jiang, and Chuanmao Zhang*.,  Geminin is partially localized to centrosome and plays a role in proper centrosome duplication. Biology of the Cell Decision Letter, 2009, 101, 273–285.
31.Yan Ma, Shang Cai, Quanlong Lu, Xuelong Lu, Qing Jiang, Jun Zhou and Chuanmao Zhang*., Inhibition of Deacetylation Impairs Microtubule-kinetochore Attachment through Interfering with Kinetochore Integrity, Centromere Function and Microtubule Behavior. Cellular and Molecular Life Sciences, 2008, 65:3100-3109.
32.Clarke PR and Zhang CM., Spatial and temporal coordination of mitosis by Ran GTPase.  Nature Review Molecular Cell Biology, 2008, 9: 467-477.
33.Qiang Chen, Xiaoyan Zhang, Qing Jiang, Paul Clarke, and Chuanmao Zhang*,  Cyclin B1 is localized to unattached kinetochores and is required for chromosome alignment during mitosis. Cell Research, 2008, 18: 268-280.
34.Lei Sun , Dengwen Li, Xin Dong , Haiyang Yu , Jin-Tang Dong ,Chuanmao Zhang , Xianyu Lu , Jun Zhou*, Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells. Biochemical Pharmacology, 2008, 75: 1027–1034.
35.Long Zhao, Xinyi Zhao, Tian Tian, Quanlong Lu, Nirma Skrbo-Larssen ,DiWu, Zheng Kuang,Xiaofeng Zheng, Yanchao Han, Shuyan Yang, Chuanmao Zhang, and Anming Meng*, Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular Research, 2008, 80:200-208.
36.Yan Ma, Shang Cai, Quanlong Lv, Xuelong Lv, Quan Zhang, Qing Jiang, Sodmergen,Zhonghe Zhai and Chuanmao Zhang*., Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β. Journal of Cell Science, 2007, 120: 520-530.
37.Jingyan Fu,Minglei Bian,Qing Jiang and Chuanmao Zhang*,  Roles of Aurora Kinases in Mitosis and Tumorigenesis. Molecular Cancer Research. 2007, 5(1). 1-10.
38.Xiaofeng Zheng, Xueyu Dai, Yanmei Zhao, Qiang Chen, Fei Lu, Deqiang Yao, Quan Yu, Xinping Liu, Chuanmao Zhang, Xiaocheng Gu, and Ming Luo*, Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc. Natl. Acad. Sci. USA (PNAS), 2007, 104(21):8809–8814
39.Zhe Liu, Hao Lin, Sheng Ye, Qin-ying Liu, Zhaohui Meng, Chuanmao Zhang, Yongjing Xia, Emanuel Margoliash, Zihe Rao, and Xiang-jun Liu*, Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis. Proc. Natl. Acad. Sci. USA (PNAS), 2006, 103: 8965–8970.
40.Chen Z, Cai S, Jiang Q, Zhang C* & Tang X., Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis. Chinese Science Bulletin., 2005, 50: 229-235
41.Zhigang Lu, Chuanmao Zhang*, and Zhonghe Zhai*, Nucleoplasmin regulates chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. USA (PNAS), 2005, 102: 2778-2783.
42.Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su., The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus. Proc. Natl. Acad. Sci. USA (PNAS) ,2005, 102:303-308.
43.Clarke, PR and Zhang, CM., Spatial and temporal control of nuclear envelope assembly by Ran GTPase. In: The Nuclear Envelope, Edited by D.E. Evans, C. Huchison & J.A. Bryant. Garland Science/Bios Scienctific Publishers, 2004.
44.Qing Jiang, Zhigang Lu and Chuanmao Zhang*. Roles of Ran GTPase in the Cell Cycle Regulation coordination. CHINESE SCI BULL, 2004, 49(6):535-541.
45.Zhigang Lu, Chuanmao Zhang (Co-corresponding Author) and Zhonghe Zhai*, LDFF, the large molecular weight DNA fragmentation factor, is responsible for the large molecular weight DNA degradation during apoptosis in Xenopus egg extracts. Cell Research, 2004, 14:134-140.
46.Yang N, Chen ZC, Lu P, Zhang CM (Corresponding Author), Zhai ZH*, Tang XW*. The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts. CHINESE SCI BULL,2003,48 (18): 1912-1918.
47.William J. Moore, Chuanmao Zhang, and Paul R. Clarke*, Targeting of RCC1 to Chromosomes Is Required for Proper Mitotic Spindle Assembly in Human Cells.  Current Biology, 2002, 12, 1442–1447.
48.Zhang, C., Goldberg, M., Moor, W., Allen, T. D., and Clarke, P. R.*, Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly. European J. Cell Biol., 2002, 81 (11): 623-633.
49.Zhang, C., and Clarke, P. R., Role of Ran GTPase in the nuclear envelope. In Nuclear Envelope Dynamics in Embryos and Somatic Cells (Ed: Philippe Collas) p59-68. 2002 EUREKEH .com and Kluwer Academic/Plenum Publishers. c
50.Zhang, C., Hutchins, JR, Mulhausser, P, Kutay, U., mand Clarke, P. R.*, Role of Importin β in the Control of Nuclear Envelope Assembly by Ran. Current Biology, 2002, 12: 498-502.
51.Clarke, PR and Zhang C., Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? Trends in Cell Biol., 2001,11:366-371.
52.Zhang, C., and Clarke, P. R., The roles of RanGDP and RanGTP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system. Current Biology, 2001, 11:208-212.
53.Zhang, C.*, and Clarke, P. R.*, Chromatin-independent Nuclear Envelope Assembly induced by RanGTPase in Xenopus Egg Extracts. Science, 2000, 288:1429-1432.
54.Zhang, C., Hughes, M., Clarke, P. R.*, Ran-GTP stablises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 1999, 112: 2453-2461.
55.Hughes, M., Zhang, C (Co-first Author), Avis, J. M., Hutchison, C. J, Clarke, P. R.*,The role of the Ran GTPase in nuclear assembly and DNA replication: Characterization of the effects of Ran mutants. Journal of Cell Science, 1998, 111:3017-3026.
56.Nicholas, F., Zhang, C., Hughes, M., Goldberg, M., Clarke, P.*, Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 1997, 110:3019-3030.
57.Zhang, Chuanmao., Gordberg, M. W., Allen, T.D., and Hutchison, C. J.*, Nuclear lamina and nuclear matrix organization in sperm pronuclei assembled in Xenopus egg extract. Journal of Cell Science, 1996, 109: 2275-2286.
执教课程
细胞生物学 , 讲课 , 北京大学 , 2002-至今,秋季
Bio2000,讲课,北京大学,2005 - 至今,春季
基础动物组织学,讲课,北京大学,2012-至今, 秋季
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