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肖俊宇
邮  箱: junyuxiao(AT)pku.edu.cn
职  称:
研究员
办公室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
个人简历
教育经历
2003 - 2008 , 理学博士 , Biological Chemistry , University of Michigan
1998 - 2002 , 理学学士 , Biochemistry and Molecular Biology , Peking University
工作经历
2014 - present , Assistant Professor/Principle Investigator , Peking University
2011 - 2013 , Assistant Project Scientist , University of California, San Diego
2009 - 2011 , Postdoctoral Scholar, Pharmacology , University of California, San Diego
科研领域描述
1.Secretory Pathway Kinases
2.Cellular Signaling
3.Structural Biology
代表性论文
1. Xiao, J., Tagliabracci, V. S., Wen, J., Kim, S. A., and Dixon, J. E. (2013). Crystal Structure of the Golgi Casein Kinase. Proc. Natl. Acad. Sci. U S A. 110(26):10574-9.
2. Xiao, J., Engel, J. L., Zhang, J., Chen, M. J., Manning, G., and Dixon, J. E. (2011). Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc. Natl. Acad. Sci. U S A. 108(29):11860-5.
3. Xiao, J., Worby, C. A., Mattoo, S., Sankaran, B., and Dixon, J. E. (2010) Structural basis of Fic mediated adenylylation. Nature Structural and Molecular Biology. 17(8):1004-10.
4. Xiao, J., Chen, X. W., Davies, B. A., Saltiel, A. R., Katzmann, D. J., and Xu, Z. (2009) Structural basis of Ist1 function and Ist1-Did2 interaction in the MVB pathway and cytokinesis. Molecular Biology of the Cell. 20(15):3514-24.
5. Xiao, J., Xia, H., Zhou, J., Azmi, I., Davies, B. A., Katzmann, D. J., and Xu, Z. (2008) Structural basis of Vta1 function in the multi-vesicular body sorting pathway. Developmental Cell. 14(1):37-49.
6. Xiao, J., Xia, H., Yoshino-Koh, K., Zhou, J., and Xu, Z. (2007) Structural Characterization of the ATPase Reaction Cycle of Endosomal AAA-Protein Vps4. J Mol Biol. 374(3):655-70.
7. Tagliabracci, V. S.#, Xiao, J.#, and Dixon, J. E. (2013) Phosphorylation of Substrates Destined for Secretion by the Fam20 Kinases. Biochem Soc Trans. 41(4):1061-5. (# Equal contribution).
8. Cui, J., Xiao, J., Tagliabracci, V. S., Wen, J., Rahdar, M., and Dixon, J. E. (2015) A secretory kinase complex regulates extracellular protein phosphorylation. Elife. 4, e06120.
9. Wen, J., Xiao, J., Rahdar, M., Choudhury, B. P., Cui, J., Taylor, G. S., Esko, J. D., and Dixon, J. E. (2014) Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc. Natl. Acad. Sci. U S A. 111(44):15723-8.
执教课程
生物化学(本科,主讲)
结构生物学(研究生,参与)

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