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吴虹
邮  箱: hongwu(AT)pku.edu.cn
职  称:
教授
实验室电话: 62765646
实验室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
个人简历
教育经历
1984 - 1991 , 博士 , 哈佛医学院
1978 - 1983 , 学士 , 北京医学院
工作经历
2013 - 至今 , 院长 , 北京大学生命科学学院
2011 - 2013 , 主任 , 美国加州大学洛杉矶分校分子医学研究所  
2009 - 至今 , David Geffen Chair in Medical Research , 美国加州大学洛杉矶分校
2008 - 2011 , 副主任 正式成员 , 美国加州大学洛杉矶分校分子医学研究所
1997 - 2004 , 助理研究员 , 霍华德-休斯医学研究所
1996 - 2013 , 助理教授、副教授、教授 , 美国加州大学洛杉矶分校分子与医学药理学系
1991 - 1996 , 博士后 , 麻省理工学院Whitehead研究所
科研领域描述
  吴虹教授是中组部千人计划全职教授,北京大学讲席教授,生命科学学院院长。吴虹教授近20年的研究重点在于探讨抑癌基因PTEN在肿瘤发生,发展及耐药中的分子机制,并取得了一系列重要的研究成果,迄今已发表研究论文160余篇,引用21700多次。她所领导的团队第一个证实PTEN在调节组织干细胞G0-G1细胞周期进入,自我更新、增殖和存活中的重要作用并将PTEN对组织干细胞的调控作用与癌症干细胞的形成联系起来。吴虹教授近期工作主要集中于研究肿瘤细胞干性获得与维持机制并寻找抑制细胞分化的关键功能分子及信号通路,研究结果可以用于肿瘤分子水平上的分类与治疗,对于肿瘤的精准治疗有重大的理论和实际意义。
代表性论文
1. Schubbert S., Jiao, J., Ruscetti, M., Nakashima, J., Wu, S., Lei, H., Xu, Q., Yi, W., Zhu, H., Wu, H. (2016) Methods for PTEN in Stem Cells and Cancer Stem Cells Methods Mol. Biol. 1288:233-85. PMID:27033080
2. Ruscetti, M., Dadashian, E.L., Guo, W., Quach, B., Mulholland D.J., Park J.W., Tran, L.M., Kobayashi, N., Bianchi-Frias, D., Nelson, P.S., Xing, Y. and Wu, H. (2015) HDAC Inhibition Impedes Epithelial-Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer. Oncogene PMID:26640144
3. Ruscetti, M., Quach, B., Dadashian, E.L., Mulholland, D.J. and Wu, H. (2015) Tracking and functional characterization of EMT and mesenchymal-like tumor cells in prostate cancer metastasis. Cancer Res. 75:2749-59. PMCID:PMC4490048.
4. Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner JE, Wu H.  Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T cell acute lymphoblastic leukemia. (2014) Cancer Res74:7048-59.PMCID:PMC4258248
5. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. (2014) A Uniform Nomenclature and Amino Acid Numbering for Human PTEN. Science Signal. 7: pe15PMCID:PMC4367864
6. Garcia, A.J., Ruscetti, M., Arenzana, T.L., Tran, L.M., Frias D.B., Sybert, E., Priceman, S.J., Wu, L., Nelson, P., Smale, S and Wu, H. (2014) Pten null prostate epithelium promotes localized MDSC expansion and immune suppression during tumor initiation and progression. Mol Cell Biol. 34:2017-2028. PMCID:PMC4019050
7. Ruscetti, M and Wu, H. (2013) PTEN in Prostate Cancer. In Prostate Cancer: Biochemistry, Molecular Biology, Genetics and Protein Reviews. Don J. Tindall (editor). Mayo Clinic (in press).
8. Mulholland, D., and Wu, H. (2013) A Book Chapter in “Stem Cells and Prostate Cancer”; Chapter 5 – Genetic and Signaling Pathway Regulations Springer Science-Business Media 77-89.
9. Smith, K.B., Tran, L.M., Tam, B.,Shurell, E.M., Li, Y., Braas, D., Tap, W.D., Christofk, H.R., Dry, S.M., Eiber, F.C., and Wu, H. (2013) Novel dedifferentiated liposarcoma xenograft models reveal PTEN down regulation as a malignant Signature and Response to PI3K Pathway Inhibition. American Journal of Pathology 182(4):1400-11. PMCID: PMC3620414.
10. Schlacher, K., Wu, H., and Jasin, M. (2012) A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2. Cancer Cell 22(1):106-16. PMID: 22789542
11. Hubner, A., Mulholland, D., Standen, C., Karasarides, M., Cavanagh-Kyros, J., Barrett, T., Chi, H., Greiner, D., Tournier, C.,  Flavell, R., Sawyers, C., Wu H., and Davis, R. (2012) JNK and PTEN co-operatively control the development of invasive adenocarcinoma of the prostate. Proc. Natl. Acad. Sci. USA109(30):12046-51. PMCID: PMC3409732
12. Mulholland, D., Kobayashi, N., Ruscetti, M., Zhi, A., Tran, L.M., Huang, J., Gleave, M and Wu, H (2012) Pten loss and RAS/MAPK activation coorperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells. Cancer Res.72 (7):1878-89. PMCID: PMC3319847
13. Tran, L.M., Chang, C., Plaisier, S., Dang, J., Mischel, P.S., Liao, J., Graeber, T.G. and Wu, H. (2012) Determining PTEN functional status by network component deducted transcription factor activities. PLoS One 7(2):e31053. PMCID: PMC 3275574
14. Donahue, T.R., Tran, M.L., Hill, R., Li, Y, Kovochich, A., Calvopina, J., Patel, S.G., Farrell, J.J., Li, X., Dawson, D. and Wu, H. (2012) Integrative survival-based molecular profiling of Human Pancreatic Cancer. Clinic Cancer Res.18(5): 1352-63. PMID: 22261810
15. Valamehr, B., Tsutsui, H., Ho, C.M., and Wu, H (2011) Developing defined culture system for human pluripotent stem cells. Regen. Med. 6:623-634. PMID: 21916597
16. Mulholland, D., Tran, M.L., Cai, H., Morim, A., Wang, S., Plaisier, S., Huang, J., Garraway, I., Graeber, T. and Wu, H. (2011) Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 19, 792-804. PMCID:PMC3157296.
17. Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H. and Jasin, M. (2011) Homologous recombination independent role for BRCA1 in blocking stalled replication folk degradation by MRE11. Cell145, 529-542. PMCID: PMC3261725
18. Le Belle, J., Orozco, N.M., Paucar, A., Saxe, J., Mottahedeh, J., Pyle, A., Wu, H. and Kornblum, H. (2011) Proliferative neural stem cell maintain high endogenous levels of reactive oxygen species that regulate self-renewal and neurogenesis in a PI3K/AKT-dependent manner. Cell Stem Cell 8 (1): 59-71.PMCID: PMC3018289
19. Guo, W., Schubbert, S., Chen, J-Y, Valamehr, V., Mosessian, S., Shi, H., Garcia, C., Theodoro, M.F., Varella-Garcia, M and Wu, H. (2011) Suppression of leukemia and leukemia stem cell transformation. Proc. Natl. Acad. Sci. USA 108, 1409-14.PMCID: PMC3029702
20. Lukacs, R., Memarzadeh, S., Wu, H. and Witte, O (2010) Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell 7(6):682-93. PMCID: PMC3019762
21. Tsutsui, H., Valamehr, B., Hindoyan, A., Qiao, R., Ding, X., Guo, S., Witte, O., Liu, X., Ho, C.M., and Wu, H. (2011) An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. Nature Communications 2:167. PMCID: PMC3161511
22. Hill, R., Calvopina, J.H., Kim, C., Wang, Y., Dawson, D.W., Donahue, T.R., Dry, S., Wu, H. (2010) PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development. Cancer Res 70 (18):7114-24.PMCID: PMC2940963
23. Gregorian, G., Nakashima, J., Dry, S.M., Nghiemphu, P.L., Smith, K.B., Ao, Y., Dang, J., Lawson, G., Mellinghoff, I.K., Mischel, P.S., Phelps, M., Parada, L., Liu, X., Sofroniew, M.V., Eilber, F.C. and Wu, H. (2009) PTEN Dosage is Essential for Neurofibroma Development and Malignant Transformation.  Proc. Natl. Acad. Sci. USA 106: 19479-84. PMCID: PMC2765459
24. Mosessian, S., Avliyakulov, N.K., Mulholland, D.J., Boontheung, P., Loo, J.A. and Wu, H. (2009) Analysis of PTEN Complex Assembly and Identification of Heterogeneous Nuclear Ribonucleoprotein C as a Component of the PTEN-associated Complex. J. Biol. Chem 284: 30159-66. PMCID: PMC2781571
25. Mulholland, D.J., Xin, L., Morim, A., Lawson, D., Witte, O., and Wu, H (2009)Lin-Sca-1+CD49high stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res 69:8555-8562. PMCID: PMC2783355
26. Guertin, D.A., Stevens, D.M., Saitoh, M., Crosby, K., Cormier, K.S., Mulholland, D.J., Magnuson, M.A., Wu, H., Sabatini, D.M. (2009) The mTOR complex 2 is required for the development of prostate cancer induced by PTEN loss in mice.  Cancer Cell 15:148-59. PMCID: PMC2701381
27. Gregorian, C., Nakashima, J., Ohab, J., Kim, R., Liu, A., Groszer, M., Garcia, D., Sofroniew, M., Carmichael, T., Liu, X. and Wu, H. (2009) Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis. J. Neuroscience 29: 1874-86. PMCID: PMC2754186
28. Valamehr, B., Jonas, S., Polleux, J., Kam, K, Qiao, R., Stiles, B., Luo, T., Witte, O., Liu, X., Dunn, B. and Wu, H. (2008) Hydrophobic Surfaces for Enhanced Differentiation of Embryonic Stem Cells. Proc. Natl. Acad. Sci. USA 105:14459-64.PMCID: PMC2567159
29. Burton JB, Johnson M, Sato M, Koh SB, Stout S, Mulholland D, Chatziioannou AF, Phelps M, Wu H. and Wu L. (2008) Adenovirus Mediated Gene Expression Imaging to Directly Detect Sentinel Lymph Node Metastasis of Prostate Cancer. Nature Med.14:882-9. PMCID: PMC2811163
30. Kwon, C.H., Zhao, D., Chen, J., Alcantara, S., Li, Y., Burns, D., Mason, R.P., Lee, E.Y-H., Wu, H and Parada, L. (2008) Ptenhaploinsufficiency accelerates formation of high grade astrocytomas. Cancer Res. 68:3286-94. PMCID: PMC2760841
31. Mulholland, D.J., Jiao, J. and Wu, H (2008) Hormone refractory prostate cancer: lesions leaned from the PTEN prostate cancer model. Adv Exp Med Biol 617:87-95. PMID:18497033
32. Chang, C., Mulholland, D., Valamehr, B., Mosessian, S., Sellers, W. andWu, H. (2008) PTEN Nuclear Localization Is Regulated by Oxidative Stress and Responsible for p53-Dependent Tumor Suppression. Mol. Cell. Biol. 28:3281-9. PMCID: PMC2423144
33. Guo, W., Lasky, J, Chang, C., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J., Chen, J., Iruela-Arispe, L., Varella-Garcia, M. and Wu, H. (2008) Multi-genetic events collaboratively to Pten-null leukaemia stem-cell formation. Nature 453: 529-533.PMCID: PMC2840044
34. Tahk S., Liu, B., Chenishof, V., Wong, K., Wu, H. and Shuai, K (2007) Control of specificity and magnitude of NF-kB and STAT1-mediated gene activation through PIASy and PIAS1 co-operation. Proc. Natl. Acad. Sci. USA 104: 11643-11648. PMCID: PMC1913887
35. Jiao, J., Wang, S., Qiao, R., Vivanco, I., Watson, P., Sawyers, C. and Wu, H. (2007) Murine Cell Lines Derived from Pten Null Prostate Cancer Demonstrate the Critical Role of PTEN in Hormone Refractory Prostate Cancer Development. Cancer Res 67: 6083-91. PMID: 17616663
36. Vivanco, I., Palaskas, N., Tran, C., Finn, S.P., Getz, G., Kennedy, N.G., Jiao, J., Rose, J., Xie, W., Loda, M., Golub, T., Mellinghoff, I., Davis, R., Wu, H. and Sawyers, C.L (2007) Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN. Cancer Cell 11: 555-569. PMID:17560336
37. He, X., Zhang, J., Grindley, J.C., Tian, Q., Sato, T., Tao, W.A., Dirisina, R., Porter-Westpfahl, K.S., Hembree, M., Johnson, T., Wiedemann, L., Barrett, T., Hood, L., Wu, H. and Li, L. (2007) Inactivation of PTEN leads to enhanced activation of intestinal stem cells and biasing on lineage fate determination. Nature Genetics 39: 189-98. PMID: 17237784
38. Freeman, D., Lesche, R., Kertesz, N., Wang, S-Y., Li, G., Gao, J., Groszer, M., Martinez-Diaz, H., Rozengurt, N., Thomas, G., Liu, X., and Wu, H. (2006) Genetic Background Controls Tumor Development in Pten Deficient Mice. Cancer Res 66: 6492-6496. PMID:16818619
39. Zhang, J., Grindley, J., Yin, T., Jayainghe, S., He, X., Ross, J., Haug, J., Rupp, D., Porter-Westpfahl, K., Wiedemann, L., Wu, H., and Li, L (2006) An essential role of PTEN in hematopoietic stem cell maintenance, lineage choice, and leukemia prevention. Nature 441: 518-522. PMID: 16633340
40. Lei, Q., Jiao, J., Xin, L., Chang, C., Wang, S., Gao, J., Gleave, M.E., Witte, O., Liu, X. and Wu, H. (2006) NKX3.1 stabilizes p53, inhibits AKT activation and delays prostate cancer initiation caused by PTEN loss. Cancer Cell 9: 367-78. PMID:16697957
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42. Li, G., Hu, Y., Liu, M., Huo, Y., Freeman, D., Gao, J., Liu, X., Wu, D-C., Wu, H. (2006) PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. J. Biol. Chem. 281:10663-10668. PMID:16507572
43. Stiles, B., Kurlawalla-Martinez, C., Guo, W., Gregorian, C., Wang, Y., Tian, J. Magnuson, M.A. and Wu, H. (2006) Selective deletion of Pten in pancreatic -cells leads to increased  cell mass and resistance to STZ-induced diabetes. Mol. Cell Biol. 26:2772-81. PMCID: PMC1430339
44. Tsai, P., Ohab, J., Kertesz, N., Groszer, M., MatterC, Gao, J., Liu, X., Wu, H. and Carmichael, S.T. (2006) A Critical Role of Erythropoietin Receptor in Neurogenesis and post-stroke recovery. J. Neurosciences 26:126901274. PMID:16436614
45. Wang, S., Garcia, A., Wu, M., Lawson, D., Witte, O. and Wu, H. (2006) Ptendeletion leads to the expansion of prostatic stem/progenitor cell subpopulation and tumor initiation. Proc. Natl. Acad. Sci. USA 103:1480-1485. PMCID: PMC1345717
46. Groszer, M., Erickson, R., Scripture-Adams, D., Dougherty, J., LeBelle, J., Zack, J., Geschwind, D., Liu, X., Kornblum, H. and Wu, H. (2006) PTEN Negatively Regulates Neural Stem Cell Self-Renewal by Modulating G0-G1 Cell Cycle Entry. Proc. Natl. Acad. Sci. USA 103:111-116. PMCID: PMC1325011
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