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魏平
邮  箱: pwei(AT)pku.edu.cn
职  称:
研究员
办公室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
实验室主页: cqb.pku.edu.cn/WeiLab/
个人简历
教育经历
2002 - 2007  北京大学, 博士 (物理化学)
1998 - 2002  南开大学,学士 (微生物学)
工作经历
2013 -     研究员, 北京大学生命科学学院/定量生物学中心
2009 - 2013 博士后, 霍华德休斯医学研究所/UCSF
2007 - 2009 博士后, 联合培养,北京大学/UCSF
代表性论文
1. Mitchell, A., Wei, P. *, Lim, A.W. *, Oscillatory stress stimulation uncovers an Achilles’ heel of the yeast MAPK signaling network. Science 2015; 350, 1379-1383. (*co-corr. author)
2. Martin, H., Shales, M., Fernandez-Pinar, P., Wei, P., Molina, M., Fiedler, D., Shokat, K. M., Beltrao, P., Lim, W., Krogan, N. J. Differential genetic interactions of yeast stress response MAPK pathways. Molecular Systems Biology 2015; 11, 800.
3. Wei, P.*, Wong, W.W.*, Park, J.S., Corcoran, E. E., Peisajovich, S. G., Onuffer, J, J., Weiss, A., Lim, W.A. , Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells , Nature , 2012 , 488, 384-388  
4. Peisajovich, S.G., Garbarino, J.E., Wei, P., Lim, W.A. , Rapid diversification of cell signaling phenotypes by modular domain recombination , Science , 2010 , 328, 368-372  
5. Wei, P., Li, C., Zhou, L., Liu Y., Lai, L. , Substrate Binding and Homo-Dimerization of SARS 3CL Proteinase are Mutual Allosteric Effectors [J] , Acta Phys. Chim. Sin. , 2010 , 26(04): 1093-1098  
6. Liang H., Chen, H., Fan, F., Wei, P., Guo, X., Jin, C., Zeng, C., Tang, C., Lai, L. , De novo design of a beta alpha beta motif , Angew Chem Int Ed Engl. , 2009 , 48(18):3301-3  
7. Chen, H.*, Wei, P.*, Huang, C., Tan, L., Liu, Y., Lai, L. , Only one protomer is active in the dimer of SARS 3C-like proteinase , J. Biol. Chem. , 2006 , 281: 13894-13898    
8. Wei, P.*, Fan, K.*, Chen, H., Ma, L., Huang, C., Tan, L., Xi, D., Li, C., Liu, Y., Cao, A., Lai, L. , The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase , Biochem. Biophys. Res. Commun , 2006 , 339: 865-872  
9. Huang, C., Wei, P., Fan, K., Liu, Y., Lai, L. , 3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism , Biochemistry , 2004 , 43: 4568-4574  
10. Fan, K.*, Wei, P.*, Feng, Q., Chen, S., Huang, C., Ma, L., Lai, B., Pei, J., Liu, Y., Chen, J., Lai, L. , Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase , J. Biol. Chem. , 2004 , 279: 1637-1642
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