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滕俊琳
邮  箱: junlinteng(AT)pku.edu.cn
职  称:
教授
办公室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
个人简历
科研领域描述
本实验室主要兴趣在于:
1. 微管相关蛋白与神经细胞的极性构建及人类疾病
2. 分子马达与神经细胞内的物质运输
3. 神经系统发育及细胞分化的分子机制

代表性论文
1. Zhou, H., Wang T., Zheng T., Teng, J*., and Chen, J*. (2016). Cep57 is a MIs12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Nat Commu 7:10151 (DOI: 10.1038/ncomms10151).
2. Chen, L., Xu, S., Xu, Y., Lu, W., Liu, L., Yue, D., Teng, J*., and Chen, J*. (2016). Cab45S promotes cell proliferation through SERCA2b inhibition and Ca2+ signaling. Oncogene 35, 35-46.
3. Lv, K., Chen, L., Li, Y., Li, Z., Zheng, P., Liu, Y., Chen, J*., and Teng, J*. (2015). Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization. J Neurosci 35, 2559-2571.
4. Wang, Q., Shen, B., Chen, L., Zheng, P., Feng, H., Hao, Q., Liu, X., Liu, L., Xu, S., Chen, J*., and Teng, J*. (2015) Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. Oncogene 34, 1006-1018.
5. Chen, L., Xu, S., Liu, L., Wen, X., Xu, Y., Chen, J*., and Teng, J*. (2014). Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP. Cell Death Dis 5, e1219.
6. Wang, Q., Shen, B., Zheng, P., Feng, H., Guo, Y., Cao, W., Chen, L., Liu, X., Zhao, G., Xu, S., Shen, W., Chen, J*., and Teng, J*. (2013.) BmCREC is an endoplasmic reticulum (ER) resident protein and required for ER/Golgi morphology. J Biol Chem 288, 26649-26657.
7. Miao, L., Teng, J*., Lin, J., Liao, X., and Chen, J*. (2013.) 14-3-3 proteins interact with neurofilament protein-L and regulate dynamic assembly of neurofilaments. J Cell Sci 126, 427-436.
8. He, R., Wu, Q., Zhou, H., Huang, N., Chen, J*., and Teng, J*. (2013). Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. J Biol Chem 288, 14384-14390.
9. He, R., Huang, N., Bao, Y., Zhou, H., Teng, J*., and Chen, J*. (2013). LRRC45 is a centrosome linker component required for centrosome cohesion. Cell Rep 4, 1100-1107.
10. Feng, H., Chen, L., Wang, Q., Shen, B., Liu, L., Zheng, P., Xu, S., Liu, X., Chen, J., and Teng, J*. (2013). Calumenin-15 facilitates filopodia formation by promoting TGF-beta superfamily cytokine GDF-15 transcription. Cell Death Dis 4, e870.
11. Wu, Q., He, R., Zhou, H., Yu, A. C., Zhang, B., Teng, J*., and Chen, J*. (2012). Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity. Cell Res 22, 1390-1401.
12. Liu, Y., Lv, K., Li, Z., Yu, A. C., Chen, J*., and Teng, J*. (2012). PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol Chem 287, 39911-39924.
13. Wang, Q., Teng, J*., Shen, B., Zhang, W., Guo, Y., Su, X., Zhang, C., Yu, A. C., and Chen, J*. (2010). Characterization of kinesin-like proteins in silkworm posterior silk gland cells. Cell Res 20, 713-727.
14. Teng, J., Rai, T., Tanaka, Y., Takei, Y., Nakata, T., Hirasawa, M., Kulkarni, A. B., and Hirokawa, N. (2005). The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol 7, 474-482.
15. Wong, W-C R., Setou, M., Teng, J., Takei, Y. and Hirokawa, N. (2002). Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci USA 99, 14500-14505.
16. Harada, A., Teng, J., Takei, Y., Oguchi, K. and Hirokawa, N. (2002). MAP2 is required for PKA anchoring in dendrites and proper PKA signal transduction. J Cell Biol 158, 541-549.
17. Teng, J., Takei, Y., Harada, A., Nakata, T., Chen, J., and Hirokawa, N. (2001). Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J Cell Biol 155, 65-76.

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