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苏晓东
邮  箱: xdsu(AT)pku.edu.cn
职  称:
教授
个人简历
科研领域描述
本实验室主要兴趣在于:
  利用X-射线晶体学手段及其它物理、化学、遗传学技术研究生物学和临床医学的基本问题;特别是研究物质代谢系统,蛋白质体内合成系统,以及与细胞凋亡和肿瘤的信号传导机制相关的蛋白质结构。
  基于结构的蛋白质工程及药物(蛋白和小分子药物)设计方法。
  利用常规及同步辐射X光源研究结构生物学方法,特别是单波长异常散射方法和低分辨率从头定相位方法;
  利用和开发不同宿主系统来表达,纯化那些重要且难于制备的蛋白分子,特别是用于结构和功能研究的糖蛋白,膜蛋白等。
  利用生化及物理学手段研究大分子相互作用及识别机理,特别是功能大分子复合物,细胞黏附,以及它们在神经系统发育,癌症发生及转移中的作用功能
    
代表性论文
1. Zixi Wang, Lanfen Li, Xiao-Dong Su* , “Structural and biochemical characterization of MdaB from Streptococcus mutans reveals a NADPH-specific quinone oxidoreductase” , Acta Crystallogr Sect D Struct Biol. , 2014 , 70(Pt 4):912-21  
2. Qin Cao, Xiao-Jun Wang, Lan-fen Li and Xiao-Dong Su* , “The regulatory mechanism of caspase-6 pro-domain revealed by crystal structure and biochemical assays” , Acta Crystallogr Sect D Struct Biol. , 2014 , 70(Pt 1):58-67.  
3. Bao ZS, Chen HM, Yang MY, Zhang CB, Yu K, Ye WL, Hu BQ, Yan W, Zhang W, Akers J, Ramakrishnan V, Li J, Carter B, Liu YW, Hu HM, Wang Z, Li MY, Yao K, Qiu XG, Kang CS, You YP, Fan XL, Li RQ, Su XD, Chen CC, Jiang T. , “RNA-Seq of 272 gliomas revealed a novel, recurrent PTPRZ-MET fusion transcript in secondary glioblastomas” Genome Research , Genome Research , 2014 , (accepted)  
4. Jin, Jian-shi; Lian, Teng-fei; Xie, Xiaoliang, Xiao-Dong Su* , “Single molecule studies of the interaction between the nucleosomal glucocorticoid response element and the glucocorticoid receptor” , J. Cell & Mol. Biol. , 2014 , (accepted)  
5. Xiao-Jun Wang, Qin Cao, Yan Zhang and Xiao-Dong Su* , “Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases” , Annu. Rev. Pharmacol. Toxicol. , 2014 , (accepted)  
6. Zixi Wang, Lanfen Li, Xiao-Dong Su* , Structure of human CLOCK-BMAL1 bHLH domains and DNA complex provides insights into protein-protein/DNA recognition and transcription control , Cell Res. , 2013 , 23(2):213-24.  
7. Zixi Wang, Lanfen Li, Xiao-Dong Su* , Structural and biochemical analysis of a noval α/β hydrolase Smu.1393c in Streptococcus mutans , Proteins. , 2013 , 82(4):695-700 doi: 10.1002/prot.24418.  
8. Kim S, Broströmer E, Xing D, Jin J, Chong S, Ge H, Wang S, Gu C, Yang L, Gao YQ, Su XD*, Sun Y*, Xie XS*. , Probing allostery through DNA.” , Science. , 2013 , 339(6121):816-9.  
9. Dong C, Zhang H, Gao ZQ, Wang WJ, She Z, Liu GF, Shen YQ, Su XD*, Dong YH* , “Structural insights into the inhibition of type VI effector Tae3 by its immunity protein Tai3.” , Biochem J , 2013 , 454(1):59-68. doi: 10.1042/BJ20130193.  
10. Zhang H, Zhang H, Gao ZQ, Wang WJ, Liu GF, Xu JH, Su XD*, Dong YH*. , Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein. , J Biol Chem. , 2013 , 288(8):5928-39.  
11. Ni X, Zhuo M, Su Z, Duan J, Gao Y, Wang Z, Zong C, Bai H, Chapman A, Zhao J, Xu L, An T, Ma Q, Wang Y, Wu M, Sun Y, Wang S, Li Z, Yang X, Yong J, Su XD, Lu Y, Bai F*, Xie XS*, and Wang J* , “Reproducible Copy Number Variation Patterns among Single Circulating Tumor Cells of Lung Cance Patients”, , PNAS 110(2013) , 2013 , pp21083-21088.  
12. Ming-Rui Duan, Jie Nan, Yu-He Liang, Peng Mao, Lu Lu, Luhua Lai, Yi Li, and Xiao-Dong Su , DNA Binding Mechanism Revealed by High Resolution Crystal Structure of Arabidopsis thaliana WRKY1 Protein , Nucleic acid research , 2012 , 35(4):1145-54  
13. Ming-Rui Duan, Jie Nan, Yu-He Liang, Peng Mao, Lu Lu, Luhua Lai, Yi Li, and Xiao-Dong Su , DNA Binding Mechanism Revealed by High Resolution Crystal Structure of Arabidopsis thaliana WRKY1 Protein , Nucleic acid research , 2012 , 35(4):1145-54  
14. Brostromer E, Nan J. and Su XD , An automated image-collection system for crystallization experiments using SBS standard microplates , Acta Crystallogr D Biol Crystallogr , 2007 , 63:119-25  
15. Brostromer E, Nan J. and Su XD , An automated image-collection system for crystallization experiments using SBS standard microplates , Acta Crystallogr D Biol Crystallogr , 2007 , 63:119-25  
16. Su XD, Liang Y, Li L, Nan J, Brostromer E, Liu P, Dong Y, Xian D , A large-scale, high-efficiency and low-cost platform for structural genomics studies , Acta Crystallogr D Biol Crystallogr , 2006 , 62(8):843-51  
17. Yu Y, Liang YH, Brostromer E, Quan JM, Panjikar S, Dong YH, Su XD , A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis , J. Biol. Chem. , 2006 , 281(48):36929-36  
18. Su XD, Liang Y, Li L, Nan J, Brostromer E, Liu P, Dong Y, Xian D , A large-scale, high-efficiency and low-cost platform for structural genomics studies , Acta Crystallogr D Biol Crystallogr , 2006 , 62(8):843-51  
19. Yu Y, Liang YH, Brostromer E, Quan JM, Panjikar S, Dong YH, Su XD , A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis , J. Biol. Chem. , 2006 , 281(48):36929-36  
20. Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su , The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus , Proc. Natl. Acad. Sci. USA (PNAS) , 2005 , 102:303-308  
21. Marcia Alvarez-Fernandez, Yuhe Liang, Magnus Abrahamson and Xiao-Dong Su , Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile , J. Biol. Chem. , 2005 , 280:18221-18228  
22. Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su , The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus , Proc. Natl. Acad. Sci. USA (PNAS) , 2005 , 102:303-308  
23. Marcia Alvarez-Fernandez, Yuhe Liang, Magnus Abrahamson and Xiao-Dong Su , Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile , J. Biol. Chem. , 2005 , 280:18221-18228  
24. Selmer, M.; and Su, X.-D , Crystal structure of an mRNA binding fragment of Moorella thermoacetica SelB , EMBO J. , 2002 , 21(15):4145-53  
25. Selmer, M.; and Su, X.-D , Crystal structure of an mRNA binding fragment of Moorella thermoacetica SelB , EMBO J. , 2002 , 21(15):4145-53  
26. Bennett, M.; Guan, Z.; Laurberg M. and Su, X-D , Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular-weight protein tyrosine phosphatases , Proc. Natl. Acad. Sci. USA (PNAS) , 2001 , 98:13577-13582  
27. Bennett, M.; Guan, Z.; Laurberg M. and Su, X-D , Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular-weight protein tyrosine phosphatases , Proc. Natl. Acad. Sci. USA (PNAS) , 2001 , 98:13577-13582
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