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邮  箱: renxwise(AT)pku.edu.cn
职  称:
副研究员
办公室电话: 62766883
办公室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
实验室电话: 62766883
实验室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
个人主页: http://zhangroup.aporc.org/XianwenRen
个人简历
教育经历
2000年9月-2004年7月,本科,南开大学,生物科学、信息与计算科学双学位
2004年9月-2007年7月,硕士,军事医学科学院,遗传学
2007年9月-2010年7月,博士,中国科学院数学与系统科学研究院,运筹学与控制论
工作经历
2010年8月-2013年8月,助理研究员,中国医学科学院病原生物学研究所
2013年9月-2016年8月,副研究员,中国医学科学院病原生物学研究所
2016年9月-至今,副研究员,北京大学生命科学学院
荣誉奖励
高等学校科学研究优秀成果奖科技进步奖一等奖(排名第三), 2016
中国医学科学院北京协和医学院协和新星, 2014
中国医学科学院病原生物学研究所先进个人, 2013
中国医学科学院北京协和医学院精神文明先进个人, 2012
代表性论文
1. Zhe Chen, Xianwen Ren, Jian Yang, Jie Dong, Ying Xue, Lilian Sun, Yafang Zhu and Qi Jin. An elaborate landscape of the human antibody repertoire against enterovirus 71 infection is revealed by phage display screening and deep sequencing. mAbs, in press.
2. Xianwen Ren, Hua Fu and Qi Jin. Integrating heterogeneous genomic data to accurately identify disease subtypes. BMC Med Genomics. 2015, 8:78 DOI:10.1186/s12920-015-0154-5.
3. Zhiqiang Wu, Li Yang, Xianwen Ren, Junpeng Zhang, Fan Yang, Shuyi Zhang and Qi Jin. ORF8-related genetic evidence for Chinese horseshoe bats as the source of human SARS coronavirus. J Infect Dis. 213 (4): 579-583 2016.
4. Zhiqiang Wu, Li Yang, Xianwen Ren, Guimei He, Junpeng Zhang, Jian Yang, Zhaohui Qian, Jie Dong, Lilian Sun, Yafang Zhu, Jiang Du, Fan Yang, Shuyi Zhang and Qi Jin. Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases. The ISME Journal 10(3):609-20 2016; doi:10.1038/ismej.2015.138
5. Yongfeng Hu, Xianwen Ren, Yingmei Liu, Fan Yang, Haiying Liu, Bin Cao and Qi Jin.
Serial high-resolution analysis of blood virome and host cytokines expression profile of a patient with fatal H7N9 infection by massively parallel RNA sequencing. Clin Microbiol Infec. 21(7):713.e1–713.e4, 2015. http://dx.doi.org/10.1016/j.cmi.2015.03.006
6. Xianwen Ren, Yongfeng, Hu, Fan Yang, Yan Xiao, Li Li, Jie Dong, Lilian Sun, Yafang Zhu and Qi Jin.
Clinical utility comparison of two benchtop deep sequencing instruments for rapid diagnosis of newly emergent influenza infections. Clin Microbiol Infec. 21(3):290.e1–290.e4, 2015.http://dx.doi.org/10.1016/j.cmi.2014.10.016
7. Li Yang, Zhiqiang Wu, Xianwen Ren, Fan Yang, Junpeng Zhang, Guimei He, Jie Dong, Lilian Sun, Yafang Zhu, Shuyi Zhang and Qi Jin. MERS–Related Betacoronavirus in Vespertilio superans Bats, China
Emerg Infect Dis. 2014 July [date cited]. http://dx.doi.org/10.3201/eid2007.140318
8. Zhiqiang Wu, Li Yang, Fan Yang, Xianwen Ren, Jinyong Jiang, Jie Dong, Lilian Sun, Yafang Zhu, Hongning Zhou and Qi Jin. Novel Henipa-like Virus, Mojiang Paramyxovirus, in Rats, China, 2012
Emerg Infect Dis, 2014 June [date cited]. http://dx.doi.org/10.3201/eid2006.131022
9. Tao Liu, Xianwen Ren, Tengfei Xiao, Jian Yang, Xingye Xu, Jie Dong, Lilian Sun, Runsheng Chen and Qi Jin. Identification and Characterisation of Non-coding Small RNAs in the Pathogenic Filamentous Fungus Trichophyton rubrum。 BMC Genomics, 14:931, 2013.
10. Xianwen Ren. Toward a more systematic understanding of bacterial virulence factors and establishing Koch postulates in silico. Virulence, 4(6):437-438.
11. Xianwen Ren, Fan Yang, Yongfeng Hu, Ting Zhang, Liguo Liu, Jie Dong, Lilian Sun, Yafang Zhu, Yan Xiao, Li Li, Jian Yang, Jianwei Wang and Qi Jin. Full Genome of Influenza A (H7N9) Virus Derived by Direct Sequencing without Culture. Emerg Infect Dis, 19(11):1881-1884, 2013.
12. Xianwen Ren, Yong Wang, Xiang-Sun Zhang, Qi Jin. iPcc: a novel feature extraction method for accurate disease class discovery and prediction. Nucleic Acids Research, 41(14):e143, 2013; doi: 10.1093/nar/gkt343.
13. Li Yang, Zhiqiang Wu, Xianwen Ren, Fan Yang, Guimei He, Junpeng Zhang, Jie Dong, Lilian Sun, Yafang Zhu, Jiang Du, Shuyi Zhang and Qi Jin. Novel SARS-like Betacoronaviruses in Bats, China, 2011
Emerg Infect Dis, 19(6), 2013.
14. Xianwen Ren, Yong Wang, Luonan Chen, Xiang-Sun Zhang and Qi Jin. ellipsoidFN: a tool for identifying a heterogeneous set of cancer biomarkers based on gene expressions. Nucleic Acids Research, 41(4): e53, 2013.
15. Xianwen Ren, Tao Liu, Jie Dong, Lilian Sun, Jian Yang, Yafang Zhu and Qi Jin. Evaluating de Bruijn graph assemblers on 454 transcriptomic data. PLoS One, 7(12): e51188, 2012.
16. Zhiqiang Wu, Xianwen Ren, Li Yang, Yongfeng Hu, Jian Yang, Guimei He, Junpeng Zhang, Jie Dong, Lilian Sun, Jiang Du, Liguo Liu, Ying Xue, Jianmin Wang, Fan Yang, Shuyi Zhang, Qi Jin. Virome Analysis for Identification of Novel Mammalian Viruses in Bat Species from Chinese Provinces. Journal of Virology 86(20): 10999-11012, 2012.
17. Xianwen Ren, Yong Wang, Jiguang Wang and Xiang-Sun Zhang. A unified computational model for revealing and predicting subtle subtypes of cancers. BMC Bioinformatics 13:70, 2012.
18. Xianwen Ren, Yongcui Wang, Yong Wang, Nai-Yang Deng and Xiang-Sun Zhang. Improving accuracy of protein-protein interaction prediction by considering the converse problem for sequence representation. BMC Bioinformatics 12:409, 2011.
19. Xianwen Ren, Xiaobo Zhou and Chung-Che Chang. The network properties of Myelodysplastic Syndromes pathogenesis revealed by an integrative systems biological method. Mol Biosyst. 2011, 7(6):2048-2054.
20. Xianwen Ren, Xiaobo Zhou, Ling-Yun Wu and Xiang-Sun Zhang. An information-flow-based model with dissipation, saturation and direction for active pathway inference. BMC Systems Biology, 4:72, 2010.
21. Xianwen Ren and Xiang-Sun Zhang. A linear programming model based on network flow for pathway inference. Journal of Systems Science and Complexity, 23(5), 971-977, 2010.
实验室简介
我们致力于用前沿的基因组学和生物信息学技术来解决癌症生物学中的重要问题,结合计算(干)和实验(湿)方法来揭示肿瘤发生过程、微环境和对药物响应中的系统变化和具体遗传因素,以推进癌症免疫治疗和靶向治疗的发展。首先,我们应用单细胞测序技术来研究肿瘤微环境,特别是浸润肿瘤免疫细胞的精确组成和功能状态,应用单细胞测序技术来研究肿瘤的异质性以及各种异质性对癌细胞的功能和药敏的影响。第二,我们将尖端生物信息学方法应用到癌症基因组学大数据中,以揭示癌症的亚型、驱动基因以及其他致癌因素的遗传基础,如基因融合、等位基因差异表达、肿瘤特有的转录异构体等,从而发现新型癌症靶点和标记物。第三,我们开发原创性的生物信息学工具来进行单细胞基因组数据和大规模癌症基因组学数据的分析、整合和可视化,为对这些数据的有效挖掘提供基础。
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