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曲红
邮  箱: quh(AT)mail.cbi.pku.edu.cn
职  称:
副教授
个人简历
教育经历
1993 - 1996 , 工学博士 , 应用化学 , 北京理工大学
1990 - 1993 , 理学硕士 , 物理化学 , 吉林大学
1986 - 1990 , 理学学士 , 有机化学 , 辽宁大学
工作经历
2000 - 至今 , 副教授 , 北京大学生命科学学院
1998 - 2000 , 讲师 , 北京大学生命科学学院
1996 - 1998 , 博士后 , 军事医学科学院药物与毒物研究所
教材编撰
实用生物统计(第2版), 李松岗、曲红编, 北大出版社, 2007
科研领域描述
1. 利用泛癌基因组数据整合分析复杂疾病中的遗传机制;
2. 系统注释和分析转运蛋白的功能及与复杂疾病的关系;
3. 构建和拓扑分析代谢转运网络;
4. 计算模拟分析生物大分子的结构和功能;
5. 验证MSKCC Nomogram预后分析模型在中国结肠癌和胃癌人群中的的适用度
6. 研究circular RNA作为竞争性内源RNA在癌症转移中的调控作用
代表性论文
1. Liu Yining, Li Zhe, Lu Jiachun, Zhao Min*, Qu Hong*. CMGene: A literature-based database and knowledge resource for cancer metastasis genes. Journal of Genetics and Genomics. 2017, 44(5): 277-279.
2. Zhao Min*, Liu Yining, Huang Fuda, Qu Hong*. A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes. Scientific Reports. 2016, 6: 30624.
3. Zhao Min*, Chen Luming, Liu Yining, Qu Hong*. GCGene: a gene resource for gastric cancer with literature evidence. Oncotarget. 2016,7(23):33983-93.
4. Zhao Min, Liu Di, Qu Hong*. Systematic review of next-generation sequencing simulators: computational tools, features and perspectives. Briefings in Functional Genomics. 2016, 16(3): 121-128.
5. Wang Aidong, Cui Ming, Qu Hong, Di Jiabo, Wang Zaozao, Xing Jiadi, Wu Fan, Wu Wei, Wang Xicheng, Shen Lin, Jiang Beihai, Su Xiangqian. Induction of anti-EGFR immune response with mimotopes identified from a phage display peptide library by panitumumab. Oncotarget. 2016, 7(46): 75293-75306.
6. Yang Chao, Xia Yu, Qu Hong, Li An-Dong, Liu Ruihua, Wang Yubo, Zhang Tong. Discovery of new cellulases from the metagenome by a metagenomics-guided strategy. Biotechnology for Biofuels. 2016, 9:138.
7. Zhao Min, Liu Yining, Qu Hong*. Expression of epithelial-mesenchymal transition-related genes increases with copy number in multiple cancer types. Oncotarget. 2016, 7(17):24688-99.
8. Zhao Min, Chen Luming, Qu Hong*. CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases. Cell Death and Disease. 2016, 7: e2053.
9. Zhao Min, Li Zhe, Qu Hong*. An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis. Scientific Reports. 2015, 5: 15478.
10. Zhao Min, Kong Lei, Liu Yining, Qu Hong*. dbEMT: an epithelial-mesenchymal transition associated gene resource. Scientific Reports. 2015, 5: 11459.
11. Zhao Min, Ma Lei, Liu Yining, Qu Hong*. PediCan: an online gene resource for pediatric cancers with literature evidence. Scientific Reports. 2015, 5: 11435.
12. Dai Jianghong, Qu Hong*, Yu Zhisheng, Yang Jiangke, Zhang Hongxun. Computational analysis of AnmK-like kinase: New insights into the cell wall metabolism of fungi. Journal of Theoretical Biology. 2015, 379: 59-65.
13. Zhao Min, Chen Yanming, Qu Dacheng*, Qu Hong*. METSP: a maximum-entropy classifier based text mining tool for transporter-substrate identification with semi-structured text. BioMed Research International. 2015, 2015: 254838.
14. Chen Xueying, Zhao Min*, Qu Hong*. Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum. BioMed Research International. 2015, 2015: 328568.
15. Liu Maoxing#, Qu Hong#, Bu Zhaode#, Chen Donglai, Jiang Beihai, Cui Ming, Xing Jiadi, Yang Hong, Wang Zaozao, Di Jiabo, Chen Lei, Zhang Chenghai, Yao Zhendan, Zhang Nan, Tan Fei, Gu Jin, Li Ziyu, Su Xiangqian. Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population. Annals of Surgical Oncology. 2015, 22(12):3881-7.
16. Zhang Haiying, Bi Guohua, Li Xia, Li Jie, Qu Hong, Zhang Shijian, Li Chuanyun, Emmanuel S Onaivi, Eliot L Gardner, Xi Zhengxiong, Liu Qingrong. Species Differences in Cannabinoid Receptor 2 and Receptor Responses to Cocaine Self-Administration in Mice and Rats. Neuropsychopharmacology. 2015, 40(4):1037-51.
17. Ye Adam Yongxin, Liu Qingrong, Li Chuanyun, Zhao Min*, Qu Hong*. Human Transporter Database: Comprehensive Knowledge and Discovery Tools in the Human Transporter Genes. PLoS One. 2014, 9(2): e88883.
18. Zhao Min, Kong Lei, Qu Hong*. A systems biology approach to identify intelligence quotient score-related genomic regions, and pathways relevant to potential therapeutic treatments. Scientific Reports. 2014, 4: 4176.
19. Zhao Min, Li Xiaomo, Qu Hong*. EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder. Science China. Life Sciences. 2013, 56(12): 1086-96.
20. He Huiying, Han Dong, Feng Hailan, Qu Hong, Song Shujuan, Bai Baojing, Zhang Zhenting. Involvement of and Interaction between WNT10A and EDA Mutations in Tooth Agenesis Cases in the Chinese Population. PLoS One. 2013, 8(11): e80393.
21. Kong Lei, Cheng Lu, Fan Liya, Zhao Min*, Qu Hong*. IQdb: an intelligence quotient score-associated gene resource for human intelligence. Database(Oxford). 2013, 2013: bat063.
22. Chen Donglai, Jiang Beihai, Xing Jiadi, Liu Maoxing, Cui Ming, Liu Yiqiang, Wang Zaozao, Chen Lei, Yang Hong, Zhang Chenghai, Yao Zhendan, Zhang Nan, Ji Jiafu, Qu Hong*, Su Xiangqian*. Validation of the memorial sloan-kettering cancer center nomogram to predict disease-specific survival after r0 resection in a chinese gastric cancer population. PLoS One. 2013, 8(10):e76041.
23. Du Fang K, Xu Fang, Qu Hong, Feng Sisi, Tang Jijun, Wu Rongling. Exploiting the Transcriptome of Euphrates Poplar, Populus euphratica (Salicaceae) to Develop and Characterize New EST-SSR Markers and Construct an EST-SSR Database. PLoS One. 2013, 8(4): e61337.
24. Chen Meiqin, Zhang Aihong, Zhang Quan, Zhang Baocai, Nan Jie, Li Xia, Liu Na, Qu Hong, Lu Cong-Ming, Sudmorgen, Zhou Yihua, Xu Zhihong, Bai Shunong. Arabidopsis NMD3 Is Required for Nuclear Export of 60S Ribosomal Subunits and Affects Secondary Cell Wall Thickening. PLoS One. 2012, 7(4): e35904.
25. Zhao Min, Qu Hong*. High similarity of phylogenetic profiles of rate-limiting enzymes with inhibitory relation in Human, Mouse, Rat, budding Yeast and E. coli. BMC Genomics. 2011, 12(Suppl 3): S10.
26. Lin Zhicheng, Juan J. Canales, Thröstur Björgvinsson, Morgane Thomsen, Qu Hong, Liu Qingrong, Gonzalo E. Torres, S. Barak Caine. Monoamine Transporters: Vulnerable and Vital Doorkeepers. In Shafiqur Rahman, editor: Progress in Molecular Biology and Translational Science, Burlington: Academic Press. 2011, 98: 1-46.
27. Tan Taochao, Xiang Xi, Qu Hong, Zhu Shenggeng, Bi Qun. The study on venom proteins of Lapemis hardwickii by cDNA phage display. Toxicology Letters. 2011, 206(3): 252-7.
28. Yang Yongkang, Qu Hong, Gao Dong, Di Wei, Chen Haiwei, Guo Xin, Zhai Zhonghe, Chen Danying. ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner. The Journal of Biological Chemistry. 2011, 286(12): 10568-80.
29. Zhao Min, Chen YanMing, Qu DaCheng, Qu Hong*. TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates. Science China. Life sciences. 2011, 54(1): 60-4.
30. Zhao Min, Qu Hong*. PathLocdb: a comprehensive database for subcellular localization of metabolic pathway and its application for multiple localization analysis. BMC Genomics. 2010, 11(Suppl 4): S13.
31. Jiang Beihai, Ren Tingting, Dong Bin, Qu Like, Jin Genglin, Li Jianning, Qu Hong, Meng Lin, Liu Caiyun, Wu Jian, Shou Chengchao. Peptide Mimic Isolated by Autoantibody Reveals Human Arrest Defective 1 Overexpression Is Associated with Poor Prognosis for Colon Cancer Patients. The American Journal of Pathology. 2010, 177(3): 1095-103.
32. Zhao Min, Qu Hong*. Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors. BMC Genomics. 2009, 10(Suppl 3): S31.
33. Song Shujuan, Han Dong, Qu Hong, Gong Y, Wu H, Zhang X, Zhong H, Feng Hailan. EDA gene mutations underlie non-syndromic oligodontia. Journal of Dental Research. 2009, 88(2): 126-31.
34. Han Dong, Gong Yu, Wu Hua, Zhang Xiaoxia, Yan Ming, Wang Xiaozhu, Qu Hong, Feng Hailan, Song Shujuan. Novel EDA mutation resulting in X-linked non-syndromic hypodontia and the pattern of EDA-associated isolated tooth agenesis. European Journal of Medical Genetics. 2008, 51(6): 536-46.
35. Jiang Bingjun, Qu Hong, Hu Yuanlei, Ni Ting, Lin Zhongping. Computational analysis of the relationship between allergenicity and digestibility of allergenic proteins in simulated gastric fluid. BMC Bioinformatics. 2007, 8:375.
36. Cui Feng, Qu Hong, Cong Jian, Liu Xiao-Li, Qiao Chuanling. Do mosquitoes acquire organophosphate resistance by functional changes in carboxylesterases?. FASEB Journal. 2007, 21(13): 3584-91.
37. Jiang Hong, Yang Chao, Qu Hong, Liu Zheng, Fu QS, Qiao Chuanling. Cloning of a Novel Aldo-Keto Reductase Gene from Klebsiella sp. Strain F51-1-2 and Its Functional Expression in Escherichia coli. Applied and Environmental Microbiology. 2007, 73(15):4959-65.
38. Bi Qun, Zhou Xue, Cen Xiaodong, Qu Hong, Luo Jingchu, Huang Yixiu, Zhu Shenggeng. Efficient targeted anticoagulant with active RGD motif. Thrombosis Research. 2007, 120(4):541-7.
39. Lei Xiaobo, Chen Yingyu, Du Guanhua, Yu Wenyu, Wang Xiaohui, Qu Hong, Xia Bin, He Hongping, Mao Jianhua, Zong Weixing, Liao Xudong, Maryam Mehrpour, Hao Xiaojiang, Chen Quan. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. FASEB Journal. 2006, 20(12):2147-9.
40. Jiang Beihai, Liu Wenbin, Qu Hong, Meng Lin, Song Shumei, Ouyang Tao, Shou Chengchao. A Novel Peptide Isolated from a Phage Display Peptide Library with Trastuzumab Can Mimic Antigen Epitope of HER-2. The Journal of Biological Chemistry. 2005, 280(6): 4656-62.
41. 由德林,曲红,陈强,邢阳,顾孝诚,罗明. 次黄嘌呤-鸟嘌呤磷酸核糖转移酶突变体的基因构建、表达和性质. 生物化学与生物物理学报. 2003, 35(9):853-858.
42. 罗敏,米志勇,曲红,唐朝荣,梁卫红,吴乃虎. 水稻Rac家族新成员osRACB基因的克隆及结构分析. 中国科学(C辑). 2003, 33(3): 202-214.
43. 许云哲,米志勇,曲红,尤瑞麟,吴乃虎. 水稻osRACD基因编码蛋白质的生化特性分析. 自然科学进展. 2003, 13(9): 923-927.
44. 周建军,曲红,吴才宏,韩卫东,李志伟,丰美福. 中国人HLA-G1的cDNA克隆、序列分析、表达和蛋白质空间结构预测. 北京大学学报(自然科学版). 2002, 38(2): 212-220.
45. Su Yanhui, Qu Hong, Vachon Vincent, Luo Jingchu, Zhang Jie, Raynald Laprade, Zhu Yuxian. The toxicity test and hypothetical model of Bacillus thuringiensis Cry1Aa helix4. Science China. Life sciences. 2002, 45(6): 561-568.
46. 吴小平,阎锡蕴,杨东玲,曲红. 人单链抗体亲和力成熟研究. 中华微生物学和免疫学杂志. 2001, 21(2): 156-159.
47. 王建民,罗静初,李毅,曲红,吴光耀,顾孝诚. 水稻矮缩病毒基因组数据库的构建. 微生物学报. 2001, 40(1): 43-48.
48. 任蕴芳,曲红,冯健男,李松,沈倍奋. 人介素-6受体胞外区配基结合功能域活性部位的设定. 科学通报. 2000, 45(3): 301-306.
49. Ren Runfang, Feng Jiannan, Qu Hong, Li Song, Shen Beifen. Three-dimensional structure and function study on the active region in the extracellular ligand-binding domain of human IL-6 receptor. Science China. Life sciences. 2000, 43(4): 425-432.
50. 邓鹏翅,吕善运,罗静初,Sandor Pongor,刘修才,曲红,梁宋平,韩汝珊,顾孝诚. alfa_淀粉酶抑制剂AAI的核磁共振氢谱谱峰归属及结构分析. 生物物理学报. 2000, 16(3), 444-452.
执教课程
生物统计 , 主讲 , 北京大学 , 2003-今
计算概论 , 主讲 , 北京大学 , 1999-2003
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