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罗冬根
邮  箱: dgluo(AT)pku.edu.cn
职  称:
研究员
办公室电话: 62760611
办公室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
实验室电话: 62768199
实验室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
个人简历
科研领域描述
  灵敏的感觉是动物生存和繁衍的基础。我们研究动物感知和行为的神经机制,包括:(1)感觉神经细胞如何将物理/化学刺激转导为神经电信号;(2)单光子或单个气味分子感知的神经机制;(3)大脑编码、加工视觉和嗅觉信号的基本原理; (4)节律行为如睡眠/觉醒和进食等的神经环路机制。
  应用神经电生理方法(活体动物大脑神经元的全细胞膜片钳记录等),结合分子遗传学、活体动物大脑双光子钙成像、动物行为学等方法,从分子、细胞、神经环路到整体动物行为研究动物感知和行为。
代表性论文
1. Yue WW, Frederiksen R, Ren X, Luo DG, Yamashita T, Shichida Y, Cornwall MC, Yau KW. Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket. eLife, 2017, 6. pii: e18492.
2. Cao LH, Jing BY, Yang D, Zeng X, Shen Y, Tu Y and Luo DG. Distinct signaling of Drosophila chemoreceptors in olfactory sensory neurons. Proc. Natl. Acad. Sci. USA, 2016, 113, E902-E911.  
3. Cao LH, Luo DG and Yau KW. Light responses of primate and other mammalian cones. Proc. Natl. Acad. Sci. USA, 2014, 111, 2752-2757.  
4. Luo DG*, Yue WWs, Ala-Laurila P and Yau KW*. Activation of visual pigments by light and heat. Science, 2011, 332, 1037-1032. (*Co-corresponding Authors)  
5. Fu Y*, Kefalov VJ*, Luo DG*, Xue T* and Yau KW. Quantal noise from human red cone pigment. Nature Neuroscience, 2008, 11, 565-571. (*Equal Contributions)  
6. Luo DG, Xue T, and Yau KW. How vision begins: an odyssey. Proc. Natl. Acad. Sci. USA, 2008, 105, 9855-9862.  
7. Su CY, Luo DG, Terakita A, Schichida Y, Liao HW, Kazmi MA, Sakamar TP and Yau KW. Parietal-eye phototransduction components and their potential evolutionary implications. Science, 2006, 311, 11617-11621.  
8. Luo DG and Yau KW. Rod sensitivity of neonatal mouse and rat. J. Gen. Physiol., 2005, 126, 263-269.  
9. Fu YB, Zhong HN, Wang MH, Luo DG, Liao HW, Maeda H, Hattar S, Frishman LJ and Yau KW. Intrinsically photosensitive retinal ganglion cells detect light with a Vitamin A-based photopigment, melanopsin. Proc. Natl. Acad. Sci. USA, 2005, 102, 10339-10344.  
10. Huttl S, Michalakis S, Seeliger M, Luo DG, Acar N, Geiger H, Hudl K, Mader R, Haverkamp S, MOser M, Pfeifer A, Gerstner A, Yau KW and Beil M. Impaired channel targeting and retinal degeneration i mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J. Neurosci., 2005, 25, 130-138.  
11. Luo DG, Li GL and Yang XL. Zn2+ modulates light responses of color-opponent bipolar and amacrine cells in the carp retina. Brain Res. Bull., 2002, 58, 461-468.  
12. Luo DG and Yang XL. Suppression by zinc of transient OFF responses of carp amacrine cells to red light is mediated by GABAa receptors. Brain Res., 2002, 958, 222-226.  
13. Luo DG and Yang XL. Zn2+ differentially modulates signals from red- and short-wavelenth-sensitive cones to horizontal cells in carp reitna. Brain Res., 2001, 900, 95-102.  
14. Xu HP, Luo DG and Yang XL. Signals from cone photoreceptors to L-tyoe horizontal cells are differntially modulated by low calcium in carp retina. Eur. J. Neurosci., 2001, 13, 1411-1419.
执教课程
生命科学学院本科生“生理学”(主讲:王世强、柴真、罗冬根);
生命科学学院本科生“高级神经生物学”(主讲:饶毅、张研、李沉简、李毓龙、罗冬根);
生命科学学院研究生“神经生物学”(主讲:张研、罗冬根);
CLS/PTN研究生“神经生物学”(感觉系统神经生物学章节)
交叉学院研究生“生物物理”(视觉感知章节);
实验室简介

Animals detect physical/chemical cues in the surroundings, and react accordingly for survival and reproduction. The LUO laboratory investigates how the animal’s sensory systems convert these cues into neuronal signals and transmit them to the brain, and how the brain then makes sense of these signals.

        Throughout evolution, sensory circuits and modalities are, by and large, conserved across species. Among model systems, we utilize a genetically-malleable species, Drosophila, wherein we can label and manipulate specific neurons, to understand sensory perception by studying its cellular, circuitry and behavioral mechanisms. As such, we aim to understand sensory processing at all levels: from molecules to behavioral responses. The genetic approach is accompanied by a state-of-the-art integrated investigation involving sensitive behavioral assays, in vivo two-photon-based calcium imaging, and patch-clamp recordings (from brain neurons of a behaving fly, and from its peripheral sensory neurons).


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