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邓宏魁
邮  箱: hongkui_deng(AT)pku.edu.cn
职  称:
教授
办公室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
个人简历
教育经历
1990 - 1995 , 理学博士 , UCLA
1984 - 1987 , 理学硕士 , 上海第二医科大学
1980 - 1984 , 理学学士 , 武汉大学
科研领域描述
本实验室主要兴趣在于:
体细胞重编程  
细胞命运调控
再生医学
Research Fields:
1. Molecular Control of Stem Cells and Cell Fate
3. Regenerative Medicine
代表性论文
1. Zhao Y, Zhao T, Guan J, Zhang X, Fu Y, Ye J, Zhu J, Meng G, Ge J, Yang S, Cheng L, Du Y, Zhao C, Wang T, Su L, Yang W, Deng H. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming. Cell, 2015, 163, 1678-91.

2. Li X, Zuo X, Jing J, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z, Zhao Y, Deng H. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015, 17:195-203.

3. Xu J, Du Y, Deng H. Direct lineage reprogramming: strategies, mechanisms, and applications.
Cell Stem Cell. 2015, 16(2):119-34. Review

4. Fang R, Liu K, Zhao Y, Li H, Zhu D, Du Y, Xiang C, Li X, Liu H, Miao Z, Zhang X, Shi Y, Yang W, Xu J, Deng H. Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts. Cell Stem Cell. 2014; 15(4):488-96.

5. Du Y, Wang J, Jia J, Song N3 Xiang C, Xu J, Hou Z, Su X, Liu B, Jiang T, Zhao D, Sun Y, Shu J, Guo Q, Yin M, Sun D, Lu S, Shi Y, Deng H , Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming , Cell Stem Cell , 2014 , 14:3 94-403  

6. Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. , Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds , Science , 2013 , 341(6146): 651-4  

7. Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C, Zhao Y, Deng H , Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell, 2013, 153(5): 963-75  

8. Sun X, Xu J, Lu H, Liu W, Miao Z, Sui X, Liu H, Su L, Du W, He Q, Chen F, Shi Y, Deng H. , Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo , Cell Stem Cell , 2013, 13(2): 230-6  

9. Zhao D, Chen S, Duo S, Xiang C, Jia J, Guo M, Lai W, Lu S, Deng H , Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects , Cell Research , 2013 , 23(1): 157-61  

10. Wang C, Tang X, Sun X, Miao Z, Lv Y, Yang Y, Zhang H, Zhang P, Liu Y, Du L, Gao Y, Yin M, Ding M, Deng H , TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy , Cell Research , 2012 , 22(1): 194-207  

11. Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res. 2011, 21(1):196-204.  

12. Yu C, Liu Y, Miao Z, Yin M, Lu W, Lv Y, Ding M, Deng H. Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors, Blood. 2010, 116(23):4786-94.

13. Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H and Ding S , Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors , Cell Stem Cell , 2009 , 4(1):16-9.

14. Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res. 2009, 19(4):429-38.

15. Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H , Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts , Cell Stem Cell , 2008 , 3(6):587-90.  

16. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H , Two supporting factors greatly improve the efficiency of human iPSC generation , Cell Stem Cell , 2008 , 3(5):475-9.  

17. Zhang P, Li J, Wang C, Tan Z, Liu T, Chen L, Yong J, Jiang W, Sun X, Ding M, Deng H, , Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2008, 111(4): 1933-41.  

18. Wang C, Faloon P, Tan Z, Lv Y. Zhang P, Deng H, Xiong J, , Mouse Lycat Controls the Development of Hematopoietic and Endothelial Lineages during in vitro ES Cell Differentiation. Blood, 2007, 110(10): 3601-9.  

19. Cai J, Zhao Y, Ye F, Liu Y, Song Zhi, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M, Deng H, , Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology, 2007, 45(5): 1229-1239.  

20. Wang C, Faloon P, Tan Z, Lv Y. Zhang P, Deng H, Xiong J, , Mouse Lycat Controls the Development of Hematopoietic and Endothelial Lineages during in vitro ES Cell Differentiation. Blood, 2007, 110(10): 3601-9.  

21. Jiang W, Shi Y, Zhao D, Chen S, Yong J, Zhang J, Qing T, Sun X, Zhang P, Ding M and Deng H. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 2007, 17(4):333-44.

22. Shi Y, Hou L, Tang F, Jiang W, Wang P, Ding M, Deng H, , Inducing Embryonic Stem Cells to Differentiate into Pancreatic Beta Cells by a Novel Three-Step Approach with Activin A and All-Trans Retinoic Acid. Stem Cells, 2005, 23(5): 656-62. 52.  

23. Deng H, Unutmaz D, Kewalramani V, Littman D , Expression cloning of novel coreceptors utilized by the simion and human immunodeficency viruses , Nature , 1997 , 388:296-300.  

24. Deng H, Liu R, Ellmeier W, Choe S, Untmaz D, Burkhart M, Marazio P, Marmon S, Sutton R., Hill C, Davis C, Peiper S, Schall T, Littman D, Landau N , Identification of a major co-receptor for primary isolates HIV-1 , Nature , 1996 , 381:661-666.
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