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朱健
邮  箱: zhua(AT)pku.edu.cn
职  称:
研究员
办公室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
个人简历
教育经历
2000 - 2005, 博士后, 发育生物学, Stanford University School of Medicine, USA
1994 - 1999, 理学博士, 分子细胞生物学, Imperial Cancer Research Fund / Imperial College London, UK
1990 - 1994, 理学荣誉学士, 生物化学, University of Aberdeen, UK
工作经历
2013 - 至今, 研究员, 北京大学-清华大学生命科学联合中心
2013 - 至今, 研究员, 北京大学生命科学学院
2006 - 2013, 助理教授, 副教授, Cleveland Clinic Lerner Research Institute / Case Western Reserve University School of Medicine, USA
荣誉奖励
2007 Basil O`Connor Starter Scholar Award, March of Dimes Foundation
2001 Walter & Idun Berry Foundation for Children`s Health Postdoctoral Fellowship
1999 Human Frontier Science Program Long-term Postdoctoral Fellowship
1994 Imperial Cancer Research Fund Postgraduate Studentship
科研领域描述
个体发育和疾病发生中信号转导网络的时空调控
  
关键词:信号转导,表观遗传,小RNA,RNA可变剪切,翻译后加工,膜泡运输,代谢调控,轴突导向,果蝇,线虫,小鼠
  
在个体发育、衰老与再生过程中,多个信号转导途径协同作用,共同调控细胞命运决定、分化与死亡。本实验室运用经典发育遗传学与细胞生物学和生物化学紧密结合的研究手段,揭示在表观遗传、小RNA、RNA可变剪切、蛋白修饰及跨膜转运等多个层次上调控信号转导途径的关键因子及其作用机理。黑腹果蝇做为一个经典的模式生物,在信号转导研究领域发挥了重要作用。在果蝇各个组织器官中,翅的发育不仅受到多种信号转导途径的综合调控,而且其高度统一的发育程式非常适合用于遗传筛选。本实验室目前采用果蝇翅的发育作为模式系统来研究信号转导途径调控网络及作用原理。由于这些信号转导途径从无脊椎到脊椎动物高度保守,并且在干细胞命运决定、个体衰老、机体代谢及肿瘤发生中起关键作用,实验室的中长期目标是解析这些信号途径调控网络与小鼠和人的发育异常以及疾病发生的相关性,从而用于疾病的诊断,药物靶点的开发和治疗。
代表性论文
1. Du, J., Zhang, J., He, T., Li, Y., Su, Y., Tie, F., Liu, M., Harte, P. J. and Zhu. A. J. (2016) Stuxnet facilitates the degradation of Polycomb protein during development. Developmental Cell, 37: 507-519 (Cover featured article).

Commented in Developmental Cell, Science China Life Sciences, and F1000Prime.
Karch, F. (2016) Stuxnet recruits the proteasome to take down Polycomb. Developmental Cell, 37: 485-486.
Wu, X. (2016) Stuxnet detected, Pc breaks down. Science China Life Sciences, 59:1202-1203.

2. Liu, M., Li, Y., Liu, A., Li, R., Su, Y., Du, J., Li, C. and Zhu, A. J. (2016) The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development. eLife, 5: e17200.

3. Zhang, J., Du, J., Lei, C., Liu, M. and Zhu, A. J. (2014) UBPY controls the stability of the ESCRT-0 subunit Hrs in development. Development, 141: 1473-1479.

4. Geisbrecht, E. R., Sawant, K., Su, Y., Liu, Z., Silver, D. L., Burtscher, A., Wang, X., Zhu, A. J. and McDonald J. A. (2013) Genetic interaction screens identify a role for Hedgehog signaling in Drosophila border cell migration. Developmental Dynamics, 242: 414-431.  

5. Zhang, J., Liu, M., Su, Y., Du, J. and Zhu, A. J. (2012) A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. G3 Genes Genomes Genetics, 2: 1563-1575 (Cover featured article).

6. Su, Y., Ospina, J. K., Zhang, J., Michelson, A., Schoen, A. M. and Zhu, A. J. (2011) Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Science Signaling, 4: ra43.

Commented in Science Signaling.
VanHook, A. M. (2011) Fine-tuning Hedgehog signaling in development and disease. Science Signaling, 4: eg10.

7. Du, J., Zhang, J., Su, Y., Liu, M., Ospina, .J. K., Yang, S. and Zhu, A. J. (2011) In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling. PLoS ONE, 6: e2416.  

8. Huang X., Suyama, K., Buchanan, J., Zhu, A. J. and Scott, M. P. (2005) A Drosophila Model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development, 132: 5115-5124.  

9. Zhu, A. J. and Scott, M. P. (2004) Incredible journey: How do developmental signals travel through tissue? Genes & Development, 18: 2985-2997 (Cover featured article).
  
10. Hwa, J. J.,* Zhu, A. J.,* Hiller, M. A., Kon, C. Y., Fuller, M. T., Santel, A. (2004) Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila. FEBS Letter, 572: 141-146 (* Co-first author).

11. Zhu, A. J., Zheng, L., Suyama, K. and Scott, M. P. (2003) Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes & Development, 17: 1240-1252 (Cover featured article).
    
Commented in Current Biology, and F1000Prime.
van den Heuvel, M. (2003) Hedgehog signaling: off the shelf modulation. Current Biology, 13: R686-R688.

12. Zhu, A. J. and Watt, F. M. (1999) β-Catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development, 126: 2285-2298.  
    
13. Zhu, A. J., Haase, I. and Watt, F. M. (1999) Signaling via β1 integrins and mitogen-activated kinase determines human epidermal stem cell fate in vitro. Proceedings of National Academy of Sciences of the United States of America, 96: 6728-6733.  

14. Zhu, A. J. and Watt, F. M. (1996) Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes, Journal of Cell Science, 109: 3013-3023.
执教课程
本科生 发育生物学, 主讲, 北大, 春季学期(48学时)
本科生 整合科学实验 (形态发生素部分), 主讲, 北大, 春季学期(32学时)

研究生SLS项目 现代生物学试验技术原理及其应用, 讲课, 北大, 秋季学期(2学时)
研究生SLS项目 科学研究规范训练, 讲课, 北大, 秋季学期(2学时)
研究生SLS项目 现代生物学基础理论 (发育生物学部分), 主讲, 北大, 春季学期(18学时)
研究生SLS项目 文献深度分析讨论 (发育生物学部分), 讲课, 北大, 春季学期(12学时)

研究生CLS项目 发育生物学基础, 主讲, 北大, 秋季学期(16学时)
研究生CLS项目 发育生物学进展, 主讲, 北大, 秋季学期(16学时)

研究生PTN项目 发育生物学模块课, 讲课, 北大, 春季学期(12学时)
实验室简介
实验室成员: 董 巍,李 硕
博士后: 刘 敏, 杜 娟
研究生: 雷 丛 (2012 CLS),李亚娟 (2013 SLS),高 远 (2013 CLS),张乐冰 (2013 CLS),何 涛 (2014 SLS),刘爱国 (2014 CLS),易梦媛 (2015 SLS),龙 婷 (2015 CLS),张思弘 (2015 CLS),张远和 (2016 SLS),范 昱 (2017 SLS),张延松 (2017 SLS)
轮转学生:牛佳浩 (PTN)
本科生: 吴锦淳 (2013),胡梦玮 (2014),李婧柔 (2015),李俊毅 (2015),梅文彬 (2015),范家豪 (2016),李 凯 (2016),王闽铭 (2016),吴奕忱 (2016)
实验室电话: (010)-6274-5121
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