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肖俊宇

邮  箱: junyuxiao@pku.edu.cn

职  称:研究员

办公室地址:北京市海淀区颐和园路5号,北京大学,吕志和楼,100871

实验室地址:北京市海淀区颐和园路5号,北京大学,吕志和楼,100871

  • 个人简介
  • 科研领域
  • 代表性论文

教育经历:

2003 - 2008 , 理学博士 , 密歇根大学
1998 - 2002 , 理学学士 , 北京大学

工作经历:

2020至今 , 长聘副教授, 北京大学
2014至今 , 研究员/独立PI, 北京大学
2014 - 2019 , 助理教授, 北京大学
2011 - 2013 , 项目科学家, 加州大学圣地亚哥分校
2009 - 2011 , 博士后, 加州大学圣地亚哥分校(导师:Jack Dixon)

执教课程:

生物化学(本科,主讲)
结构生物学(研究生,参与)

      1. Secretory pathway kinases
2. Immunoglobulins
3. Structural biology
1. Li, Y., Wang, G., Li, N., Wang, Y., Zhu, Q., Chu, H., Wu, W., Tan, Y., Yu, F., Su, X.D., Gao, N., Xiao, J.* (2020) Structural insights into immunoglobulin M. Science 367:1014-1017.
2. Banerjee, S., Wei, T., Wang, J., Lee, J.J., Gutierrez, H.L., Chapman, O., Wiley, S.E., Mayfield, J.E., Tandon, V., Juarez, E.F., Chavez, L., Liang, R., Sah, R.L., Costello, C., Mesirov, J.P., de la Vega, L., Cooper, K.L., Dixon, J.E.*, Xiao, J.*, Lei, X*. (2019). Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression. Proc Natl Acad Sci U S A 116:24881-24891.
3. Ji, C., Du, S., Li, P., Zhu, Q., Yang, X., Long, C., Yu, J., Shao, F.*, Xiao, J.* (2019). Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8. PLoS Pathog. 15:e1007876.
4. Liang, K., Li, N., Wang, X., Dai, J., Liu, P., Wang, C., Chen, X.W., Gao, N., Xiao, J.* (2018). Cryo-EM structure of human mitochondrial trifunctional protein. Proc Natl Acad Sci U S A 115:7039-7044.
5. Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M.J., Guo, X., Tagliabracci, V.S., Dixon, J.E., Xiao, J.* (2018). Structure and evolution of the Fam20 kinases. Nature Communications 9:1218.
6. Liu, Y., Bhowmick, T., Liu, Y., Gao, X., Mertens, H.D.T., Svergun, D.I., Xiao, J.*, Zhang, Y.*, Wang, J.H.*, Meijers, R*. (2018). Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. Neuron. 97(6):1261-1267.
7. Du, S., Qu, L.J., Xiao, J.* (2018). Crystal structures of the extracellular domains of the CrRLK1L receptor-like kinases ANXUR1 and ANXUR2. Protein Sci. 27:886-892.
8. Sun, X., Li, Y., He, W., Ji, C., Xia, P., Wang, Y., Du, S., Li, H., Raikhel, N., Xiao, J.*, Guo, H.* (2017). Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nature Communications 8:15758.
9. Cui, J., Zhu, Q., Zhang, H., Cianfrocco, M.A., Leschziner, A.E., Dixon, J.E.*, Xiao, J.* (2017). Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. eLife 6, e23990.
10. Zhu, Q., Venzke, D., Walimbe, A.S., Anderson, M.E., Fu, Q., Kinch, L.N., Wang, W., Chen, X., Grishin, N.V., Huang, N., Yu, L., Dixon, J.E., Campbell, K.P.*, Xiao, J.* (2016). Structure of protein O-mannose kinase reveals a unique active site architecture. eLife 5, e22238.

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