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张蔚

邮  箱: weizhangvv@pku.edu.cn

职  称:研究员

办公室电话:62767697

办公室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

实验室电话:62767697

实验室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

  • 个人简介
  • 科研领域
  • 代表性论文

教育经历:

2001-2005 学士,山东大学生命科学学院
2005-2011 博士,北京大学生命科学学院

荣誉奖励:

億方学者,2019
北京大学优秀班主任,2019
芝加哥大学博士后联合会奖学金,2014

工作经历:

2018年-至今 研究员 北京大学生命科学学院
2018年-至今 研究员 北大清华生命科学联合中心
2012年-2017年 博士后 芝加哥大学生态与演化系
2012年 博士后 芝加哥大学儿科系

执教课程:

现代生物学理论基础-演化与组学(研、SLS),春季
文献深度分析讨论课程-演化与组学(研、SLS),春季
生物信息学(研、PTN),讲课,春季
生物演化(本),讲课,秋季
      我们的研究兴趣在于整合实验和计算生物学的研究方法,探究重要演化问题的理论基础和分子机理,例如物种形成,适应性性状以及渗入演化。我们的研究对象通常具有物种丰富,适应性辐射以及不完全生殖隔离等特点。例如,鳞翅目昆虫物种丰富,存在广泛种间杂交,并且具有多样的翅膀花纹,是用于研究适应性演化的经典体系。测序技术和基因编辑技术的迅速发展,使得对于非模式生物在全基因组层面进行演化基因组学和群体遗传学研究以及进行目标基因的功能鉴定成为可能。我们的主要研究方向包括:叶形拟态的起源和遗传机制;鳞翅目昆虫发育过程的雌雄二型;适应性基因渐渗的鉴定,功能研究和演化模型等。
(* equal contribution, # corresponding author)
Yang J*, Wan W*, Xie M*, Mao J*, Dong Z*, Lu S, He J, Xie F, Liu G, Dai X, Chang Z, Zhao R, Zhang R, Wang S, Zhang Y, Zhang W#, Wang W#, Li X#. Chromosome-level reference genome assembly and gene editing of the dead-leaf butterfly. Mol. Ecol. Resour. 2020 May 12. doi: 10.1111/1755-0998.13185.
Mullen SP#, VanKuren NW, Zhang W, Nallu S, Kristiansen EB, Wuyun Q, Liu K, Hill RI, Briscoe AD, Kronforst MR. Disentangling population history and character evolution among hybridizing lineages. Mol. Biol. Evol. 2020 Jan 13. pii: msaa004. doi: 10.1093/molbev/msaa004.
Zhang W#, Leon-Ricardo BX, van Schooten B, Van Belleghem SM, Counterman BA, McMillan WO, Kronforst MR, Papa R. Comparative transcriptomics provides insights into reticulate and adaptive evolution of a butterfly radiation. Genome Biol. Evol. 2019 Sep 13. 11(10):2963-2975. doi: 10.1093/gbe/evz202.
Chen J*#, Huang Y*, Brachi B*, Yun Q*, Zhang W, Lu W, Li H, Li W, Sun X, Wang G, He J, Zhou Z, Chen K, Ji Y, Shi M, Sun W, Yang Y#, Zhang R#, Abbott RJ#, Sun H#. Genome-wide analysis of Cushion willow provides insights into alpine plant divergence in a biodiversity hotspot. Nat. Commun. 2019 Nov 19;10(1):5230. doi: 10.1038/s41467-019-13128-y.
Westerman E*, VanKuren N*, Massardo D, Tanger-Trolander A, Zhang W, Hill RI, Perry M, Bayala E, Barr K, Chamberlain N, Douglas TE, Buerkle N, Palmer S, Kronfost MR#. Aristaless controls butterfly wing color variation used in mimicry and mate choice. Curr. Biol. 2018 Nov 5;28(21):3469-3474.e4. doi: 10.1016/j.cub.2018.08.051.
Nallu S, Hill JA, Don K, Sahagun C, Zhang W, Meslin C, Snell-Rood E, Clark NL, Morehouse NI, Bergelson J, Wheat CW, Kronforst MR#. The molecular genetic basis of herbivory between butterflies and their host-plants. Nat. Ecol. Evol. 2018 Sep;2(9):1418-1427. doi: 10.1038/s41559-018-0629-9. (Reported by Nature Plants)
Zhang W, Westerman E, Nitzany E, Palmer S, Kronforst MR#. Tracing the origin and evolution of supergene mimicry in butterflies. Nat. Commun. 2017 Nov 7;8(1):1269. (Reported by University of Chicago, PBS, and ScienceDaily)
Zhang W#, Dasmahapatra KK, Mallet J, Moreira GR, Kronforst MR#. Genome-wide introgression among distantly related Heliconius butterfly species. Genome Biol. 2016 Feb 27;17(1):25. (Research highlighted by Genome Biology)
Li X*, Fan D*, Zhang W*, Liu G*, Zhang L*, Zhao L, Fang X, Chen L, Dong Y, Chen Y, Ding Y, Zhao R, Feng M, Zhu Y, Feng Y, Jiang X, Zhu D, Xiang H, Feng X, Li S, Wang J, Zhang G, Kronforst MR#, Wang W#. Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. Nat. Commun. 2015 Sep 10;6:8212.
Zhan S#, Zhang W, Niitepold K, Hsu J, Fernández Haeger J, Zalucki M, Altizer S, De Roode J, Reppert S, Kronforst MR#. The genetics of monarch butterfly migration and warning colouration. Nature. 2014 Oct 16;514(7522):317-21. (Reported by Nature News & Views, Science Magazine, NY Times, National Geographic, Washington Post and NBC News)
Kunte K*#, Zhang W*, Tenger-Trolander A, Palmer D, Martin A, Reed RD, Mullen SP, Kronforst MR#. doublesex is a mimicry supergene. Nature. 2014 Mar 13;507(7491):229-32. (Recommended by Faculty of 1000, reported by Nature News & Views, Nature Magazine, Science Magazine, NY Times, LA Times, Chicago Tribune and University of Chicago and included in An Introduction to Molecular Evolution and Phylogenetics, 2016 Edition and Genetics: From Genes to Genomes (Hartwell), 2017 Edition)
Kronforst MR#, Hansen MEB, Crawford NG, Gallant JR, Zhang W, Kulathinal RJ, Kapan DD, Mullen SP#. Hybridization reveals the evolving genomic architecture of speciation. Cell Rep. 2013 Nov 14;5(3):666-77. (Selected as Cell Report Best of 2013 and reported by Science Magazine, The Economist, LA Times and University of Chicago)
Zhang W, Kunte K, Kronforst MR#. Genome-wide characterization of adaptation and speciation in tiger swallowtail butterflies using de novo transcriptome assemblies. Genome Biol. Evol. 2013;5(6):1233-45. doi: 10.1093/gbe/evt090. (Cover Story)
Yang C, Zhang W, Ren M, Song L, Li T#, Zhao J#. Whole-genome sequence of Microcystis aeruginosa TAIHU98, a nontoxic bloom-forming strain isolated from Taihu Lake, China. Genome Announ. 2013 Jun 1(3). pii: e00333-13.
Hu Y, Zhang X, Shi Y, Zhou Y, Zhang W, Su XD, Xia B, Zhao J#, Jin C#. Structures of Anabaena calcium-binding Protein CcbP: insights into Ca2+ signaling during heterocyst differentiation. J Biol. Chem. 2011 Apr 286(14): 12381-12388.
Shi Y*, Zhao W*, Zhang W, Ye Z, Zhao J#. Regulation of intracellular free calcium concentration during heterocyst differentiation by HetR and NtcA in Anabaena sp. PCC 7120. Proc. Natl. Acad. Sci. USA 2006 Jul 103(30): 11334-11339.

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