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高宁

邮  箱: gaon@pku.edu.cn

职  称:教授

办公室电话:62744236

办公室地址:北京市海淀区颐和园路5号,北京大学,吕志和楼,100871

实验室电话:62744236

实验室地址:北京市海淀区颐和园路5号,北京大学,吕志和楼,100871

  • 个人简介
  • 科研领域
  • 代表性论文
  • 实验室简介

教育经历:

2001-2006,博士,生物医学系,纽约州立大学奥尔巴尼分校
1996-2000,学士,生命科学学院,北京大学

荣誉奖励:

2019 中组部第四批万人计划,科技创新领军人才
2018 科技部中青年科技创新领军人才
2018 教育部高等学校科学研究优秀成果奖—青年科学奖
2018 2017年度教育部特聘教授
2017 谈家桢生命科学创新奖
2017 国家自然科学基金杰出青年基金
2016 茅以升北京青年科技奖
2016 中源协和生命医学创新突破奖
2016 药明康德生命化学学者奖
2014 国家自然科学基金委优秀青年基金
2013 北京市高等学校青年英才计划
2006 Distinguished Doctoral Dissertation Award, SUNY at Albany

工作经历:

2017/4-至今,教授,北京大学生命科学学院
2017/4-至今,研究员,北京大学-清华大学联合生命中心
2008/11-2017/3,特别副研究员、助理教授、副教授(with tenure),教授,清华大学生命科学学院
2006-2008,博士后,纽约州Wadsworth Center,霍华德休斯医学研究所,哥伦比亚大学生化和分子生物物理系
          高宁实验室主要致力于阐明细胞内大型蛋白-核酸复合物形成的分子机器的精细结构及工作分子机制,近年来的科研工作着重于核糖体的生物生成(ribosome biogenesis)、蛋白质生物合成的调控、DNA复制起始调控等重要基础生物学过程。实验室主要采用冷冻电镜三维重构的方法分析大型复合物的高分辨结构,辅助遗传学、细胞生物学、生化分子生物学手段回答大分子机器在功能执行过程中的机制性问题。
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实验室围绕着生命科学的核心内容,主要运用冷冻电镜技术研究与重大生命过程相关的分子机器的结构和功能,探索重要的基础生物学机制问题及相关的人类重大疾病的发生机制。近年来,实验室的科研工作聚焦于核酸-蛋白复合物分子机器及组成复杂的大型蛋白复合物。实验室的重要研究领域包括:

(1)病原体的核糖体是很多抗菌药物的天然靶点,同时人源核糖体生物生成(ribosome biogenesis)也在多种人类肿瘤细胞中异常上调,并且和肿瘤转移的能力正相关。实验室以细菌、酵母、人源细胞系作为模型,研究人类病原体、模式生物以及人类核糖体的生物组装机制,不同核糖体结合蛋白在蛋白翻译中的新颖调控功能和分子机制,以及潜在药物靶标的发现;

(2)DNA复制是分子生物学的核心环节,DNA复制的紊乱也是众多肿瘤的一项标志性特征。实验室研究真核生物DNA复制起始过程的蛋白质分子机器的结构和工作机制。

(3)实验室同时也和众多课题组紧密合作,包括临床科学家,研究人类重大疾病治疗靶点的结构和机制。


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