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季雄

邮  箱: xiongji@pku.edu.cn

职  称:研究员

实验室地址:北京市海淀区颐和园路5号,北京大学,吕志和楼,100871

  • 个人简介
  • 科研领域
  • 代表性论文
  • 实验室简介

教育经历:

2004-2008,本科,生物技术,武汉大学
2009-2012,联合培养博士,加州大学圣地亚哥分校
2008-2013,博士,生物化学与分子生物学,武汉大学

荣誉奖励:

2013, 吴瑞奖学金
2013, 湖北省优秀博士论文
2017, 億方学者
2017-2022, 国家重点研发计划专项青年项目,首席科学家

工作经历:

2013-2016,博士后,麻省理工白头生物医学研究所
2016-现在,研究员,北京大学生命科学学院
2016-现在,研究员,北大-清华生命科学联合中心

执教课程:

近代分子生物学史话
细胞核的结构与功能
      研究兴趣包括RNA聚合酶亚基、三维功能基因组及相分离相关的基因表达调控机理。以早期胚胎干细胞和癌症细胞为模型,运用基因组学、蛋白质组学、生物信息学、计算机模拟、CRISPR基因编辑、光学成像和生物化学等多学科技术开展RNA聚合酶亚基调控的分子机理、动态变化和疾病的相关研究。主要致力于:
1. RNA聚合酶亚基新型功能的系统鉴定与分子机理研究  
2. RNA聚合酶亚基与人类重大疾病及抗病毒免疫
3. RNA聚合酶亚基相关的药物筛选
1. Huang, J., Jiang, Y., Zheng, H., Ji, X.*, BAT Hi-C Maps Global Chromatin Interactions in An Efficient and Economical Way. Methods, 2020 Jan 1; 170: 38-47.
2. Zhang, H.*, Ji, X.*, Li, P.*, Liu, C.*, Lou, J.*, Wang, Z., Wen, W.*, Xiao, Y., Zhang,M.*, Zhu, X.*, Liquid-liquid Phase Separation in Biology: Mechanisms, Physiological Functions and Human Diseases. Science China Life Sciences. 2020 April 30.
3. Jiang, Y., Huang, J., Lun, K., Li, B., Li, Y., Zheng, H., Li, Y., Zhou, R., Duan, W., Wang, C., Feng, Y., Yao, H., Li, C., Ji, X.*, Genome-wide Analyses of ChromatinInteractions After the Loss of Pol I, Pol II and Pol III. Genome Biology, in press.
4. Ji, X., Dadon, D.B., Powell, B.E., Fan, Z.P., Borges-Rivera, D., Shachar, S., Weintraub, A.S., Hnisz, D., Pegoraro, G., Lee, T.I., et al. (2016). 3D Chromosome Regulatory Landscape of Human Pluripotent Cells. Cell Stem Cell 18, 262-275.
5. Ji, X., Dadon, D.B., Abraham, B.J., Lee, T.I., Jaenisch, R., Bradner, J.E., and Young, R.A. (2015). Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proceedings of the National Academy of Sciences of the United States of America 112, 3841-3846.
6. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C.Y., Xiao, R., Burge, C.B., and Fu, X.D. (2013). SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell 153, 855-868.
7. Liu, X.S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R.A., and Jaenisch, R. (2016). Editing DNA Methylation in the Mammalian Genome. Cell 167, 233-247 e217.
8. Sigova, A.A., Abraham, B.J., Ji, X., Molinie, B., Hannett, N.M., Guo, Y.E., Jangi, M., Giallourakis, C.C., Sharp, P.A., and Young, R.A. (2015). TranscrIption factor trapping by RNA in gene regulatory elements. Science 350, 978-981.
9. Fong, N., Kim, H., Zhou, Y., Ji, X., Qiu, J., Saldi, T., Diener, K., Jones, K., Fu, X.D., and Bentley, D.L. (2014). Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate. Genes Development 28, 2663-2676.
10. Wang, Y., Jiang, L., Ji, X., Yang, B., Zhang, Y., and Fu, X.D. (2013). Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes. The Journal of biological chemistry 288, 18484-18493.
11. Mo, S., Ji, X., and Fu, X.D. (2013). Unique role of SRSF2 in transcription activation and diverse functions of the SR and hnRNP proteins in gene expression regulation. Transcription 4, 251-259.
12. Ji, X., and Fu, X.D. (2012). The mediator couples transcription and splicing. Molecular Cell 45, 433-434.
13. Han, J., Ji, X., Wang, D., and Fu, X.D. (2011). Pre-mRNA splicing: where and when in the nucleus. Trends in Cell Biology 21, 336-343.
14. Xue, Y., Zhou, Y., Wu, T., Zhu, T., Ji, X., Kwon, Y.S., Zhang, C., Yeo, G., Black, D.L., Sun, H., et al. (2009). Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Molecular Cell 36, 996-1006.


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