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罗述金

邮  箱: Luo.shujin@pku.edu.cn

职  称:研究员

办公室电话:62752307

办公室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

实验室电话:62752307

实验室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

实验室主页:http://luo-lab.org

  • 个人简介
  • 科研领域
  • 代表性论文
  • 实验室简介

教育经历:

2006,博士,保护生物学,美国明尼苏达大学
1998,学士,生物化学与分子生物学,北京大学

工作经历:

2016至今, 北京大学生命科学学院, 长聘副教授/研究员
2016至今, 北京大学-清华大学生命科学联合中心, 高级研究员
2011-2016,北京大学-清华大学生命科学联合中心,研究员
2009-2016,北京大学生命科学学院,助理教授/研究员
2009,世界自然基金会(WWF-US)物种保护项目,黑龙江流域生态区虎/豹保护项目官员
2007-2009,美国国立卫生研究院(NIH)-国家癌症研究所(National Cancer Institute, NCI),博士后

执教课程:

普通生物学B(本科生课程,建议文科类学生选修,春季)
分子生态学(本科生和研究生课程,秋季)
      基因组多样性和演化

物种通过其基因组多样性所决定的表型多样性而适应不同的环境。了解生物适应性的自然规律和遗传基础,对于生物演化和多样性的研究至关重要。我们利用现代遗传学方法,重构物种在种群水平的演化模式,推断演化过程,研究与物种的表型、行为、种群历史和系统分类等相关的基本科学问题。目前的研究主要侧重于以分子生物学和种群遗传学为基础,结合传统生态学、生物地理学和系统分类学的背景,研究野生及驯化哺乳动物类群尤其是猫科动物的基因组多样性和适应性的遗传学机理,具体体现在以下研究方向:

1. 猫科动物及其他物种表型多样性的遗传机制和基因组学研究
2. 野生动物基因组多样性、演化和种群遗传学研究
3. 中国野生猫科动物的保护生物学

实验室更多信息请见: http://luo-lab.org
1. Luo SJ*, Liu YC, Xu X (2019). Tigers of the world: genomics and conservation. Annual Review of Animal Biosciences 7: 521-548. [Invited Review]
2. Liu YC, Sun X, Driscoll C, Miquelle DG, Xu X, Martelli P, Uphyrkina O, Smith JLD, O’Brien SJ, Luo SJ* (2018). Genome-wide evolutionary analysis of natural history and adaptation in the world’s tigers. Current Biology 28(23):3840-3849. [Cover Story]
3. Gaubert P*, Antunes A*, Meng H, Miao L, Peigne S, Justy F, Njiokou F, Dufour S, Danquah E, Alahakoon J, Verheyen E, Stanley WT, O’Brien SJ, Johnson WE, Luo SJ* (2018). The complete phylogeny of pangolins: scaling up resources for the molecular tracing of the world’s most trafficked mammals on Earth. Journal of Heredity 109(4): 347-359. [Cover Story]
4. Yu H, Song S, Liu J, Li S, Zhang L, Wang D, Luo SJ* (2017). Effects of the Qinghai-Tibet railway on the landscape genetics of the endangered Przewalski’s gazelle (Procapra przewalskii). Scientific Reports 7:17983 | DOI:10.1038/s41598-017-18163-7
5. Xu X, Dong GX, Schmidt-Kuntzel A, Zhang XL, Zhuang Y, Fang R, Sun X, Hu XS, Zhang TY, Yang HD, Zhang DL, Marker L, Jiang ZF, Li R, Luo SJ* (2017). The genetics of tiger pelage color variations. Cell Research 27: 954-957.
6. Gaubert P, Njiokou F, Ngua G, Afiademanyo K, Dufour S, Malekani J, Bi SG, Tougard C, Olayemi A, Danquah E, Djagoun CAMS, Kaleme P, Mololo CN, Stanley W, Luo SJ, Antunes A (2016). Phylogeography of the heavily poached African common pangolin (Pholidota, Manis tricuspis) reveals six cryptic lineages as traceable signatures of Pleistocene diversification. Molecular Ecology 25: 5975-5993.
7. Choo SW, Rayko M, Tan TK, Hari R, Komissarov A, Wee WY, Yurchenko A, Kliver S, Tamazian G, Antunes A, Wilson RK, Warren WC, Koepfli KP, Minx P, Krasheninnikova K, Kotze A, Dalton DL, Vermaak E, Paterson IC, Dobrynin P, Sitam FT, Japning JRR, Johnson WE, Yusoff AM, Luo SJ, Karuppannan KV, Fang G, Zheng D, Gerstein MB, Lipovich L, O’Brien SJ, Wong GJ. (2016). Pangolin genomes and the evolution of mammalian scales and immunity. Genome Research 26: 1-12.
8. Xu X, Sun X, Hu XS, Zhuang Y, Liu YC, Meng H, Miao L, Yu H, Luo SJ* (2016). Whole genome sequencing identifies a missense mutation in HES7 associated with short tails in Asian domestic cats. Scientific Reports 6: 31583 | DOI: 10.1038/srep31583
9. Zou ZT, Uphyrkina O, Fomenko P, Luo SJ* (2015). The development and application of a multiplex short tandem repeat (STR) system for identifying subspecies, individuals and sex in tigers. Integrative Zoology 10: 376–388.
10. Xue HR, Yamaguchi N, Driscoll CA, Han Y, Bar-Gal GK, Zhuang Y, Mazak JH, Macdonald DW, O’Brien SJ, Luo SJ* (2015). Genetic ancestry of the extinct Javan and Bali tigers. Journal of Heredity 106(3): 247-257.
11. Zhang MQ, Xu X*, Luo SJ* (2014). The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens). Animal Genetics 45(5): 652-659.
12. Luo SJ*, Zhang Y, Johnson WE, Miao L, Martelli P, Antunes A, Smith JLD, O’Brien SJ* (2014). Sympatric Asian felid phylogeography reveals a major Indochinese-Sundaic divergence. Molecular Ecology 23(8): 2072-2092.
13. Cho YS, Hu L, Hou H, Lee H, Xu J, Kwon S, Oh S, Kim HM, Jho S, Kim S, Shin YA, Kim BC, Kim H, Kim CU, Luo SJ, Johnson W, and 42 others (2013). The tiger genome and comparative analysis with lion and snow leopard genomes. Nature Communications 4: 2433.
14. Xu X, Dong GX, Hu XS, Miao L, Zhang XL, Zhang DL, Yang HD, Zhang TY, Zou ZT, Zhang TT, Zhuang Y, Bhak J, Cho YS, Dai WT, Jiang TJ, Xie C, Li R*, Luo SJ*(2013). The genetic basis of white tigers. Current Biology 23(11): 1031-1035. [Cover Story and Featured in Cell, 154: 257-259, Learning from Exotic Species]
15. Driscoll CA, Luo SJ, MacDonald D, Dinerstein E, Chestin I, Pereladova O, O`Brien SJ (2011). Restoring tigers to the Caspian region. Science 333: 822-823. [Letter to editor]
16. Luo SJ*, Johnson WE, O’Brien SJ (2010). Applying molecular genetic tools to tiger conservation. Integrative Zoology 5: 351-362. [Invited Review]
17. Driscoll CA, Yamaguchi N, Bar-Gal GK, Roca AL, Luo SJ, Macdonald DW, O’Brien SJ (2009). Mitochondrial phylogeography illuminates the origin of the extinct Caspian tiger and its relationship to the Amur tiger. PLoS One 4(1): e4125.
18. Luo SJ*, Johnson WE, Martenson J, Antunes A, Martelli P, Uphyrkina O, Traylor-Holzer K, Smith JLD, O’Brien SJ* (2008). Subspecies genetic assignments of worldwide captive tigers increase conservation value of captive populations. Current Biology 18(8): 592-596. [Cover Story]
19. Luo SJ*, Johnson WE, David VA, Menotti-Raymond M, Stanyon R, Cai QX, Beck T, Yuhki N, Pecon-Slattery J, Smith JLD, O’Brien SJ* (2007). Development of Y chromosome intraspecific polymorphic markers in the Felidae. Journal of Heredity 98(5): 400-413.
20. Luo SJ, Cai QX, David VA, Zhang L, Martelli P, Lim NTL, Ferrand N, Chin SC, Gaubert P, Joao Ramos M, O’Brien SJ, Antunes A, Johnson WE (2007). Isolation and characterization of microsatellite markers in pangolins (Mammalia, Pholidota, Manis spp.). Molecular Ecology Notes 7(2): 269-272.
21. Luo SJ*, Kim JH, Johnson WE, Miquelle DG, Huang SQ, Pan WS, Smith JLD, O’Brien SJ (2006). Proceedings in phylogeography and genetic ancestry of tigers (Panthera tigris) in China and across their range. Zoological Research 27(4): 441-448. [in Chinese, Cover Story]
22. Luo SJ, Kim JH, Johnson WE, van der Walt J, Martenson J, Yuhki N, Miquelle DG, Uphyrkina O, Goodrich JM, Quigley HB, Tilson R, Brady G, Martelli P, Subramaniam V, McDougal C, Hean S, Huang SQ, Pan W, Karanth UK, Sunquist M, Smith JLD, O’Brien SJ (2004). Phylogeography and genetic ancestry of tigers (Panthera tigris). PLoS Biology 2 (12): 2275-2293/e442. [Cover Story]
基因组多样性和演化实验室成立于2009年,以猫科动物基因组学和保护生物学研究为核心,具备分子生物学和生物信息学干湿实验综合实力。实验室建有生物样品库及数据库管理系统、古DNA超净平台、基因组数据处理计算服务器等硬件设施;在高通量数据分析、动物基因组组装与注释、群体基因学、基因与性状关联性分析、连锁遗传定位等有丰富的数据分析经验;且能有效开展分子生物学、生化和细胞水平的功能实验。

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