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罗冬根

邮  箱: dgluo@pku.edu.cn

职  称:研究员

办公室电话:62760611

办公室地址:北京市海淀区颐和园路5号,北京大学,吕志和楼,100871

实验室电话:62768199

实验室地址:北京市海淀区颐和园路5号,北京大学,吕志和楼,100871

  • 个人简介
  • 科研领域
  • 代表性论文
  • 实验室简介

执教课程:

生命科学学院本科生“生理学”(主讲:王世强、柴真、罗冬根);
生命科学学院本科生“高级神经生物学”(主讲:饶毅、张研、李沉简、李毓龙、罗冬根);
生命科学学院研究生“神经生物学”(主讲:罗冬根);
生命科学学院研究生“感觉神经生物学进展”(主讲:罗冬根);
CLS/PTN研究生“神经生物学”(感觉系统神经生物学章节)
交叉学院研究生“生物物理”(视觉感知章节);
      我们研究动物感知和行为的神经机制,包括:(1)感觉神经系统如何将物理/化学刺激转导为神经电信号;(2)大脑编码、加工感觉信号的基本原理; (3)节律行为如生物钟、睡眠/觉醒和进食的神经机制。
    
应用电生理方法(活体动物大脑神经元的多电极膜片钳记录等),结合分子遗传学、活体动物大脑双光子钙成像、动物行为学等方法,从分子、细胞、环路到整体动物行为多层次系统地研究动物感知和行为的基本规律。
1. Zhou Y, Cao LH, Sui XW, Guo XQ, and Luo DG. Mechanosensory circuits coordinate two opposing motor actions in Drosophila feeding. Science Advances 2019, 5: eaaw5141.

2. Li MT, Cao LH, Xiao N, Tang M, Deng B, Yang T, Yoshii T, and Luo DG. Hub-organized parallel circuits of central circadian pacemaker neurons for visual photoentrainment in Drosophila. Nature Communications 2018, 9: 4247.

3. Cao LH, Yang D, Wu W, Zeng X, Jing BY, Li MT, Qin SS, Tang C, Tu Y, and Luo DG. Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila. Nature Communications 2017, 8: 1357.

4. Yue WW, Frederiksen R, Ren X, Luo DG, Yamashita T, Shichida Y, Cornwall MC, Yau KW. Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket. eLife, 2017, 6. pii: e18492.

5. Cao LH, Jing BY, Yang D, Zeng X, Shen Y, Tu Y and Luo DG. Distinct signaling of Drosophila chemoreceptors in olfactory sensory neurons. Proc. Natl. Acad. Sci. USA, 2016, 113, E902-E911.

6. Cao LH, Luo DG and Yau KW. Light responses of primate and other mammalian cones. Proc. Natl. Acad. Sci. USA, 2014, 111, 2752-2757.

7. Luo DG*, Yue WWs, Ala-Laurila P and Yau KW*. Activation of visual pigments by light and heat. Science, 2011, 332, 1037-1032. (*Co-corresponding Authors)

8. Fu Y*, Kefalov VJ*, Luo DG*, Xue T* and Yau KW. Quantal noise from human red cone pigment. Nature Neuroscience, 2008, 11, 565-571. (*Equal Contributions)

9. Luo DG, Xue T, and Yau KW. How vision begins: an odyssey. Proc. Natl. Acad. Sci. USA, 2008, 105, 9855-9862.

10. Su CY, Luo DG, Terakita A, Schichida Y, Liao HW, Kazmi MA, Sakamar TP and Yau KW. Parietal-eye phototransduction components and their potential evolutionary implications. Science, 2006, 311, 11617-11621.

11. Luo DG and Yau KW. Rod sensitivity of neonatal mouse and rat. J. Gen. Physiol., 2005, 126, 263-269.

12. Fu YB, Zhong HN, Wang MH, Luo DG, Liao HW, Maeda H, Hattar S, Frishman LJ and Yau KW. Intrinsically photosensitive retinal ganglion cells detect light with a Vitamin A-based photopigment, melanopsin. Proc. Natl. Acad. Sci. USA, 2005, 102, 10339-10344.

13. Huttl S, Michalakis S, Seeliger M, Luo DG, Acar N, Geiger H, Hudl K, Mader R, Haverkamp S, MOser M, Pfeifer A, Gerstner A, Yau KW and Beil M. Impaired channel targeting and retinal degeneration i mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J. Neurosci., 2005, 25, 130-138.

14. Luo DG, Li GL and Yang XL. Zn2+ modulates light responses of color-opponent bipolar and amacrine cells in the carp retina. Brain Res. Bull., 2002, 58, 461-468.

15. Luo DG and Yang XL. Suppression by zinc of transient OFF responses of carp amacrine cells to red light is mediated by GABAa receptors. Brain Res., 2002, 958, 222-226.

16. Luo DG and Yang XL. Zn2+ differentially modulates signals from red- and short-wavelenth-sensitive cones to horizontal cells in carp reitna. Brain Res., 2001, 900, 95-102.

17. Xu HP, Luo DG and Yang XL. Signals from cone photoreceptors to L-tyoe horizontal cells are differntially modulated by low calcium in carp retina. Eur. J. Neurosci., 2001, 13, 1411-1419.

My laboratory is interested in the neural mechanisms underlying animal sensation and behavior. We study: 1) the molecular mechanisms of converting physical/chemical cues into neuronal responses, 2) the principles of sensory coding and processing, and 3) the circuits of rhythmic behaviors such as circadian clock, sleep/wake, and feeding.

 

We use a genetically-malleable species, Drosophila, wherein we can label and manipulate specific neurons, to understand sensation and behavior from molecules to circuits to behaviors. The genetic approach is accompanied by a state-of-the-art integrated investigation involving optogenetic/chemogenetic manipulation, circuit tracing, two-photon-based calcium imaging, behavioral test and in vivo multi-electrode patch-clamp recordings.




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