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韦玉生

邮  箱: yusheng.wei@pku.edu.cn

职  称:副研究员

办公室电话:62763133

办公室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

实验室电话:62763133

实验室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

  • 个人简介
  • 科研领域
  • 代表性论文

教育经历:

2001 – 2004, 理学博士 , 生物化学与分子生物学 , 北京协和医学院
1998 – 2001, 理学硕士 , 生物化学与分子生物学 , 兰州大学
1994 - 1998, 理学学士 , 生物化学 , 兰州大学

工作经历:

2004.9 – 2008.4, 助理研究员, 医学分子生物学国家重点实验室 中国医学科学院基础所
2008.5 – 2012.11 博士后, 美国麻省总医院 哈佛医学院/纽约西奈山医学院
2013.11 - 2019.05, 副研究员 , 北京大学
2019.06 - 至今, 高级工程师, 北京大学
      1. 利用基因修饰大、小鼠动物模型研究重要转录调控因子在心脏发育以及心血管疾病中的作用与分子机理;
2. 动物细胞基因编辑技术改进与大、小鼠基因修饰动物模型平台的优化建立。
1. Yusheng Wei*, Siwu Peng*, Ravi Sachidanandam, Zhidong Tu, Shihong Zhang, Christine Falce, Eric Sobie, Djamel Lebeche, Yong Zhao. Multifaceted roles of miR-1s in repressing the fetal gene program in the heart. Cell Research. 2014, 24(3): 278-292. (#co-first author).
2. Ya-Jun Li*, Yu-Sheng Wei*, Xiang-Hui Fu, De-Long Hao, Zhen Xue, and De-Pei Liu, Chih-Chuan Liang. The apoCIII enhancer regulates both the extensive histone modification and intergenic transcripts of human apoAI/CIII/AIV genes but not apoAV. J Biol Chem. 2008, 283(42):28436-44. ( *co-first author )
3. Jun Gao*, Yusheng Wei*, Yue Huang , Depei Liu, Guang Liu, Min Wu , Lin Wu, Qingjun Zhang, Zhuqin Zhang, Ran Zhang, Chihchuan Liang.The expression of intact and mutant human apolipoprotein AI/CIII/AIV/AV gene cluster in transgenic mice. J Biol Chem. 2005, 280(13): 12559-66. ( *co-first author ).
4. Wei Zheng, Yun-Biao Lu, Shu-Ting Liang, Qing-Jun Zhang, Jing Xu, Zhi-Gang She, Zhu-Qin Zhang, Rui-Feng Yang, Bei-Bei Mao, Zhen Xu, Li Li, De-Long Hao, Jie Lu, Yu-Sheng Wei, Hou-Zao Chen, De-Pei Liu. SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes. Basic Res Cardiol. 2013;108(4):364-9.
5. Shuang Zhou, Hou-Zao Chen, Yan-zhen Wan, Qing-Jun Zhang, Yu-Sheng Wei, Shuai Huang, Jin-Jing Liu, Yun-Biao Lu, Zhu-Qin Zhang, Rui-Feng Yang, Ran Zhang, Hua Cai, De-Pei Liu, Chih-Chuan Liang. . Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res. 2011, 109(6):639-48.
6. Li Li, Hui-Na Zhang, Hou-Zao Chen, Peng Gao, Li-Hua Zhu, Hong-Liang Li, Xiang Lv, Qing-Jun Zhang, Ran Zhang, Zhao Wang, Zhi-Gang She, Ran Zhang, Yu-Sheng Wei, Guan-Hua Du, De-Pei Liu, Chih-Chuan Liang. SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res. 2011, 13;108(10):1180-9.
7. Wei Zhou, Ying Zhang, Yiping Li, Yu-Sheng Wei, Guang Liu, De-Pei Liu, Samuel J Pleasure, Wei Xie, Chunjie Zhao. A transgenic Cre mouse line for the study of cortical and hippocampal development. Genesis. 2010, 48(5):343-50.
8. Ran Zhang, Hou-Zao Chen, Jin-Jing Liu, Yu-Yan Jia, Zhu-Qin Zhang, Rui-Feng Yang, Yuan Zhang, Jing Xu, Yu-Sheng Wei, De-Pei Liu and Chih-Chuan Liang. SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem. 2010, 285(10):7097-110.
9. Zhi-Gang She, Wei Zheng, Yu-Sheng Wei, Hou-Zao Chen, Ai-Bing Wang, Hong-Liang Li, Guang Liu, Ran Zhang, Jin-Jing Liu, William B. Stallcup, Zhongjun Zhou, De-Pei Liu, Chih-Chuan Liang. Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice. Circ Res. 2009, 104(10):1160-8.
10. Qing-jun Zhang, Zhao Wang, Hou-zao Chen, Shuang Zhou, Wei Zheng, Guang Liu, Yu-sheng Wei, Hua Cai, De-pei Liu, Chih-chuan Liang. Endothelium-specific Overexpression of Class III Deacetylase SIRT1 Decreases Atherosclerosis in ApoE Deficient Mice. Cardiovasc Res. 2008, 80(2):191-9.
11. Hong-Liang Li, Ming-Lei Zhuo, Dong Wang, Ai-Bing Wang, Li-Hong Sun, Qinglin Yang, Yue Huang, Yu-Sheng Wei, De-Pei Liu,Chih-Chuan Liang. Overexpression of A20 Improves Left Ventricular Performance and Reduces Compensatory Hypertrophy after Myocardial Infarction. Circulation, 2007, 115(14):1885-94

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