Dr. Long Li published a paper in Cell Research.
In summary, the structure of the TIM22 complex reveals a sophisticated organization of the seven subunits. Tim18-Sdh3 and Tim22 provide a docking platform for anchoring Tim9-Tim10-Tim12. Tim9-Tim10-Tim12 is at the center of the assembly, likely to receive the polypeptide substrates from Tim9-Tim10 and pass them to Tim22. Tim54 helps to hold Tim9-Tim10-Tim12 in a tilted conformation. Tim22 may create a hydrophilic environment either inside a channel or in the membrane to facilitate TM insertion.
