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PTEN in Regulating Hematopoiesis and Leukemogenesis

Nov.21,2019

Prof. Hong Wu published a paper in Cold Spring Harbor Perspectives in Medicine.


PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. By counteracting the PI3K/AKT/mTOR pathway, PTEN plays an essential role in regulating hematopoietic stem cells (HSCs) self-renewal, migration, lineage commitment, and differentiation. PTEN also plays important roles in suppressing leukemogenesis, especially T-cell acute lymphoblastic leukemia (T-ALL). Herein, we will review the function of PTEN in regulating hematopoiesis and leukemogenesis and discuss potential therapeutic approaches against leukemia with PTEN mutations.


Original link: http://perspectivesinmedicine.cshlp.org/content/early/2019/11/11/cshperspect.a036244.long