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Biology is one of the oldest disciplines at PKU, which originated from the Imperial University of Peking (founded in 1898), the first national comprehensive university in China.

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Research News MORE>>

Hub-organized parallel circuits of central circadian pacemaker neurons for visual photoentrainment in Drosophila

Oct 15，2018

Circadian rhythms are orchestrated by a master clock that emerges from a network of circadian pacemaker neurons. The master clock is synchronized to external light/dark cycles through photoentrainment, but the circuit mechanisms underlying visual photoentrainment remain largely unknown. Here, we rep...

Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation

Oct 15，2018

The Mre11–Rad50–Nbs1 (MRN) complex is well known for participating in DNA damage response pathways and mediating the ATM-dependent phosphorylation signaling cascade. Hypomorphic mutations in the human MRN complex have been identified in autosomal recessive genetic diseases, ataxia-telangiectasia–...

Biosynthetic energy cost for amino acids decreases in cancer evolution

Oct 15，2018

Rapidly proliferating cancer cells have much higher demand for proteinogenic amino acids than normal cells. The use of amino acids in human proteomes is largely affected by their bioavailability, which is constrained by the biosynthetic energy cost in living organisms. Conceptually distinct from gen...

An OB-fold complex controls the repair pathways for DNA double-strand breaks

Oct 15，2018

53BP1 with its downstream proteins, RIF1, PTIP and REV7, antagonizes BRCA1-dependent homologous recombination (HR) and promotes non-homologous end joining (NHEJ) in an unclear manner. Here we show that REV7 forms a complex with two proteins, FAM35A and C20ORF196. We demonstrate that FAM35A preferent...

lecture MORE>>

Oct
16

Pan-cancer Genomic and Neoepitope Landscape of Pediatric Cancers

Speaker：Jinghui Zhang, Ph.D.

Time：13:00-14:30

Location：Youcai Deng Hall, School of Life Sciences

Oct
12

Feeling force with the mechanosensitive Piezo channels

Speaker：Bailong Xiao, PhD

Time：13:00-14:30

Location：Youcai Deng Hall, School of Life Sciences

Sep
18

Cell division and genome organization in development and aging

Speaker：Yixian Zheng, Ph.D.

Time：13:00-14:30

Location：Youcai Deng Hall，School of Life Sciences

Sep
03

Cryo-electron microscopy -- a journey to high resolution without crystals

Speaker：Joachim Frank, Ph.D.

Time：09:30-11:00

Location：Youcai Deng Hall，School of Life Sciences

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