北京大学 | ENGLISH
讲座信息
CFTR, the odd ABC transporter responsible for cystic fibrosis
发布时间:2018-07-20      点击量:867
主讲人:Zhe Zhang
讲座地点:金光生命科学大楼411
讲座日期:2018-09-04
讲座时间:13:30 — 14:30
 
生命科学学院学术报告
题目:CFTR, the odd ABC transporter responsible for cystic fibrosis
讲座人:Zhe Zhang
Postdoctoral Associate
The Howard Hughes Medical Institute and the Rockefeller University
时间:2018年9月4日(星期二)13:30-14:30
地点:金光生命科学大楼411
摘要:
Cystic fibrosis (CF) is the most common lethal genetic disorder in populations of Northern European descent, affecting one out of every 2,500 newborns. It is caused by mutations in a single gene, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR belongs to the ATP-binding cassette (ABC) transporter superfamily, but it is unique among ABC proteins in that it functions as an anion channel. We solved the cryo-EM structures of CFTR in two functional states: the dephosphorylated, ATP-free (closed) and the phosphorylated, ATP-bound (flicker-closed) conformations. By correlating with a mass of functional studies people have done, we get strong insights into the understanding of how CFTR evolves from transporter to channel as well as its gating mechanism.
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