讲座时间：13:30 — 14:30
题目：CFTR, the odd ABC transporter responsible for cystic fibrosis
The Howard Hughes Medical Institute and the Rockefeller University
Cystic fibrosis (CF) is the most common lethal genetic disorder in populations of Northern European descent, affecting one out of every 2,500 newborns. It is caused by mutations in a single gene, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR belongs to the ATP-binding cassette (ABC) transporter superfamily, but it is unique among ABC proteins in that it functions as an anion channel. We solved the cryo-EM structures of CFTR in two functional states: the dephosphorylated, ATP-free (closed) and the phosphorylated, ATP-bound (flicker-closed) conformations. By correlating with a mass of functional studies people have done, we get strong insights into the understanding of how CFTR evolves from transporter to channel as well as its gating mechanism.