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讲座信息
Glucose sensing and redefinition of AMPK
发布时间:2017-03-08      点击量:585
主讲人:林圣彩
讲座地点:北京大学英杰交流中心306会议室
讲座日期:2017-03-14
讲座时间:16:00 — 17:30
联系人:刘颖 (Tel. 6276-6523)
 
IMM & CLS Research Seminar
Title:Glucose sensing and redefinition of AMPK
Speaker:林圣彩 教授
厦门大学生命科学学院院长
Time:2017年3月14日(星期二)下午4:00-5:30
Place:北京大学英杰交流中心306会议室
Host:北京大学分子医学研究所  刘颖 (Tel. 6276-6523)
Abstract:
Glucose is the major source for energy, and is a precursor for the synthesis of many biomolecules. On entering glycolysis, glucose is converted in three steps to fructose-1,6-bisphosphate (FBP), which is then split into triose phosphates by FBP aldolases. Glucose deprivation activates AMP-activated protein kinase (AMPK), a sensor of cellular energy that monitors levels of AMP, ADP and ATP and plays a primary role in adaptive responses to energy stress, but it has been unclear how glucose deprivation activates AMPK. I will present our identification of a glucose-sensing pathway that triggers AMPK activation in an AMP/ADP-independent manner. This has caused a major paradigm shift in our understanding of the roles of AMPK in nutrient- and energy-sensing, and prompted us to reflect on the different levels of AMPK function.
欢迎各位老师同学积极参加!

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